Advancements in Drug Treatment for Adenomyosis

Yang Guo(Graduate School of Zunyi Medical University)
Xiao Yanbing(Zunyi Maternal and Child Health Hospital)

Abstract

Adenomyosis is a common gynecological disease causing secondary dysmenorrhea, menstrual irregularities, and infertility. Traditionally, the treatment of adenomyosis has been primarily surgical; however, with the deepening understanding of the disease and the contemporary demand for fertility preservation, non-surgical treatments are gaining more attention. Pharmacotherapy, a key non-surgical approach, encompasses diverse strategies such as hormonal agents, anti-hormonal drugs (e.g., gonadal axis suppressants/blockers), non-steroidal anti-inflammatory drugs (NSAIDs), and traditional Chinese medicine (TCM). It plays a crucial role in managing adenomyosis, enhancing patients' quality of life, and preserving fertility.

In recent years, traditional Chinese medicine (TCM) and the integration of TCM with Western medicine have demonstrated unique advantages in adenomyosis management. Traditional Chinese medicine considers the main cause of adenomyosis to be "blood stagnation in the uterus," leading to poor circulation of qi and blood, which causes symptoms such as dysmenorrhea and menstrual abnormalities. The treatment principle is to invigorate blood circulation and resolve stasis, warming the meridians to improve qi and blood circulation, combined with lifestyle adjustments and other comprehensive interventions. The team has long been committed to clinical research on the grading treatment of adenomyosis, proposing the concept and approach of the "Danhuang San Plan," which integrates traditional and Western medicine based on the principles of Western medicine's gonadal axis suppression/blocking treatment and traditional Chinese medicine's invigorating blood circulation and resolving stasis, achieving good results and providing references for preserving the uterus and fertility in adenomyosis treatment. This article reviews the current status of drug treatment for adenomyosis and the team's related concepts and research results, aiming to provide references for non-surgical treatment of adenomyosis and support the practical need for fertility preservation in adenomyosis.  

Keywords

Adenomyosis; Drug treatment; Traditional and Western medicine treatment; Danhuang San Plan

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Author Introduction: Yang Guo, female, born on November 1, 1990, Miao nationality, from Fenghuang County, Hunan Province, holds a bachelor's degree and is a chief physician specializing in gynecology and obstetrics.

DOI: http://dx.doi.org/10.26549/jams.v8i2.33849