Online Interventions for Post-Traumatic:A Systematic Review
Abstract
Post-traumatic stress disorder (PTSD) is common, yet access to face-to-face psychological treatment is limited. Online interventions provide an alternative for PTSD patients. This meta-analysis reviewed 46 randomized controlled trials published in English or Chinese since 2000. Seven types of online interventions were examined, including cognitive behavioral therapy (CBT), expressive writing, Interapy, cognitive performance tasks, psychosocial interventions, psychoeducation, and mindfulness. Four outcomes were analyzed: PTSD total score, intrusion, avoidance, and hyperarousal.
Results showed that CBT and Interapy were the most effective compared with passive controls, followed by psychosocial interventions and expressive writing. Online interventions were more effective than passive controls but not significantly better than active controls. Dropout rates suggested good patient acceptance. Subgroup analyses found no significant differences between cancer and non-cancer patients or between parental and non-parental groups receiving CBT. Although findings are promising, more studies are needed to explore different therapeutic approaches, effects on negative cognition and post-traumatic growth, and the development of individualized online interventions based on trauma type and personalityKeywords
References
Kessler RC, Aguilar-Gaxiola S, Alonso J, Benjet C, Bromet EJ, Cardoso G, Degenhardt L, Dinolova RV, Ferry F, Florescu S, Gureje O, Koenen KC. Trauma and PTSD in the WHO World Mental Health Surveys. Eur J Psychotraumatol. 2017 Oct 27;8(sup5):1353383.
Kessler, R.C., Berglund, P., Delmer, O., Jin, R., Merikangas, K.R., & Walters, E.E. (2005). Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in NationalComorbidity Survey. Archives of General Psychiatry, 62(6): 593-602.
Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB. Posttraumatic stress disorder
in the National Comorbidity Survey. Arch Gen Psychiatry. 1995 Dec;52(12):1048-60.
Pineles SL, Mostoufi SM, Ready CB, Street AE, Griffin MG, Resick PA.
Trauma reactivity, avoidant coping, and PTSD symptoms: a moderating relationship?
J Abnorm Psychol. 2011 Feb;120(1):240-6.
Bourne C, Mackay CE, Holmes EA. The neural basis of flashback formation: the impact of viewing trauma. Psychol Med. 2013 Jul;43(7):1521-32.
Kensinger EA, Corkin S. Two routes to emotional memory: distinct neural processes for valence and arousal. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3310-5. doi: 10.1073/pnas.0306408101. Epub 2004 Feb 23. PMID: 14981255; PMCID: PMC365786.
Kimble M, Boxwala M, Bean W, Maletsky K, Halper J, Spollen K, Fleming K. The impact of hypervigilance: evidence for a forward feedback loop. J Anxiety Disord. 2014 Mar;28(2):241-5.
Olthuis JV, Watt MC, Bailey K, Hayden JA, Stewart SH. Therapist-supported Internet cognitive behavioural therapy for anxiety disorders in adults. Cochrane Database Syst Rev. 2015 Mar 5;(3):CD011565.
Khan AM, Dar S, Ahmed R, Bachu R, Adnan M, Kotapati VP. Cognitive Behavioral Therapy versus Eye Movement Desensitization and Reprocessing in Patients with Post-traumatic Stress Disorder: Systematic Review and Meta-analysis of Randomized Clinical Trials. Cureus. 2018 Sep 4;10(9):e3250.
Wang Z, Wang J, Maercker A. Chinese My Trauma Recovery, a Web-based intervention for traumatized persons in two parallel samples: randomized controlled trial. J Med Internet Res. 2013 Sep 30;15(9):e213.
Roy MJ, Highland KB, Costanzo MA. GETSmart: Guided Education and Training via Smart Phones to Promote Resilience. Stud Health Technol Inform. 2015;219:123-8.
Christensen H, Griffiths KM, Mackinnon AJ, Kalia K, Batterham PJ, Kenardy J, Eagleson C, Bennett K. Protocol for a randomised controlled trial investigating the effectiveness of an online e health application for the prevention of Generalised Anxiety Disorder. BMC Psychiatry. 2010 Mar 21;10:25.
Amstadter AB, Broman-Fulks J, Zinzow H, Ruggiero KJ, Cercone J. Internet-based interventions for traumatic stress-related mental health problems: a review and suggestion for future research. Clin Psychol Rev. 2009 Jul;29(5):410-20.
Littleton H, Grills AE, Kline KD, Schoemann AM, Dodd JC. The From Survivor to Thriver program: RCT of an online therapist-facilitated program for rape-related PTSD. J Anxiety Disord. 2016 Oct;43:41-51.
Stefanopoulou E, Lewis D, Mughal A, Larkin J. Digital Interventions for PTSD Symptoms in the General Population: a Review. Psychiatr Q. 2020 Dec;91(4):929-947.
Bisson J, Andrew M. Psychological treatment of post-traumatic stress disorder. Cochrane Database Syst Rev. 2007;3.
Brunet A, Saumier D, Liu A, Streiner DL, Tremblay J, Pitman RK. Reduction of PTSD Symptoms With Pre-Reactivation Propranolol Therapy: A Randomized Controlled Trial. Am J Psychiatry. 2018 May 1;175(5):427-433.
Lange A, Rietdijk D, Hudcovicova M, van de Ven JP, Schrieken B, Emmelkamp PM. Interapy: a controlled randomized trial of the standardized treatment of posttraumatic stress through the internet. J Consult Clin Psychol. 2003 Oct;71(5):901-9. doi: 10.1037/0022-006X.71.5.901. PMID: 14516238.
Wang Z, Wang J, Maercker A. Chinese My Trauma Recovery, a Web-based intervention for traumatized persons in two parallel samples: randomized controlled trial. J Med Internet Res. 2013 Sep 30;15(9):e213.
Baikie KA, Geerligs L, Wilhelm K. Expressive writing and positive writing for participants with mood disorders: an online randomized controlled trial. J Affect Disord. 2012 Feb;136(3):310-9.
Graf MC, Gaudiano BA, Geller PA. Written emotional disclosure: a controlled study of the benefits of expressive writing homework in outpatient psychotherapy. Psychother Res. 2008 Jul;18(4):389-99.
Gonçalves R, Pedrozo AL, Coutinho ES, Figueira I, Ventura P. Efficacy of virtual reality exposure therapy in the treatment of PTSD: a systematic review. PLoS One. 2012;7(12):e48469.
Lewis C, Roberts NP, Bethell A, Robertson L, Bisson JI. Internet-based cognitive and behavioral therapies for post-traumatic stress disorder (PTSD) in adults. Cochrane Database Syst Rev. 2018 Dec 14;12(12):CD011710.
Varker T, Brand RM, Ward J, Terhaag S, Phelps A. Efficacy of synchronous telepsychology interventions for people with anxiety, depression, posttraumatic stress disorder, and adjustment disorder: A rapid evidence assessment. Psychol Serv. 2019 Nov;16(4):621-635.
Kuester A, Niemeyer H, Knaevelsrud C. Internet-based interventions for posttraumatic stress: A meta-analysis of randomized controlled trials. Clin Psychol Rev. 2016 Feb;43:1-16.
Beck CT. Secondary traumatic stress in nurses: a systematic review. Arch Psychiatr Nurs. 2011 Feb;25(1):1-10.
Lin L, Chu H. Quantifying publication bias in meta-analysis. Biometrics. 2018 Sep;74(3):785-794.
Bowden J, Davey Smith G, Burgess S. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol. 2015 Apr;44(2):512-25.
Duval S, Tweedie R. Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics. 2000 Jun;56(2):455-63.
Beatty L, Koczwara B, Wade T. Evaluating the efficacy of a self-guided Web-based CBT intervention for reducing cancer-distress: a randomised controlled trial. Support Care Cancer. 2016 Mar;24(3):1043-51.
Carpenter KM, Stoner SA, Schmitz K, McGregor BA, Doorenbos AZ. An online stress management workbook for breast cancer. J Behav Med. 2014 Jun;37(3):458-68.
Cernvall M, Carlbring P, Ljungman L, Ljungman G, von Essen L. Internet-based guided self-help for parents of children on cancer treatment: a randomized controlled trial. Psychooncology. 2015 Sep;24(9):1152-8.
Eisma MC, Boelen PA, van den Bout J, Stroebe W, Schut HA, Lancee J, Stroebe MS. Internet-Based Exposure and Behavioral Activation for Complicated Grief and Rumination: A Randomized Controlled Trial. Behav Ther. 2015 Nov;46(6):729-48.
Ivarsson D, Blom M, Hesser H, Carlbring P, Enderby P, Nordberg R, Andersson G. Guided internet-delivered cognitive behavior therapy for post-traumatic stress disorder: A randomized controlled trial. Internet Interventions. 2014 March;1(1):33-40.
Kersting A, Dölemeyer R, Steinig J, Walter F, Kroker K, Baust K, Wagner B. Brief Internet-based intervention reduces posttraumatic stress and prolonged grief in parents after the loss of a child during pregnancy: a randomized controlled trial. Psychother Psychosom. 2013;82(6):372-81.
Kersting A, Kroker K, Schlicht S, Baust K, Wagner B. Efficacy of cognitive behavioral internet-based therapy in parents after the loss of a child during pregnancy: pilot data from a randomized controlled trial. Arch Womens Ment Health. 2011 Dec;14(6):465-77.
Knaevelsrud C, Böttche M, Pietrzak RH, Freyberger HJ, Kuwert P. Efficacy and Feasibility of a Therapist-Guided Internet-Based Intervention for Older Persons with Childhood Traumatization: A Randomized Controlled Trial. Am J Geriatr Psychiatry. 2017 Aug;25(8):878-888.
Littleton H, Grills A. Changes in Coping and Negative Cognitions as Mechanisms of Change in Online Treatment for Rape-Related Posttraumatic Stress Disorder. J Trauma Stress. 2019 Dec;32(6):927-935.
Litz BT, Engel CC, Bryant RA, Papa A. A randomized, controlled proof-of-concept trial of an Internet-based, therapist-assisted self-management treatment for posttraumatic stress disorder. Am J Psychiatry. 2007 Nov;164(11):1676-83.
Litz BT, Schorr Y, Delaney E, Au T, Papa A, Fox AB, Morris S, Nickerson A, Block S, Prigerson HG. A randomized controlled trial of an internet-based therapist-assisted indicated preventive intervention for prolonged grief disorder. Behav Res Ther. 2014 Oct;61:23-34.
Spence J, Titov N, Dear BF, Johnston L, Solley K, Lorian C, Wootton B, Zou J, Schwenke G. Randomized controlled trial of Internet-delivered cognitive behavioral therapy for posttraumatic stress disorder. Depress Anxiety. 2011 Jul;28(7):541-50.
Spence J, Titov N, Johnston L, Jones MP, Dear BF, Solley K. Internet-based trauma-focused cognitive behavioural therapy for PTSD with and without exposure components: a randomised controlled trial. J Affect Disord. 2014 Jun;162:73-80.
Sveen J, Andersson G, Buhrman B, Sjöberg F, Willebrand M. Internet-based information and support program for parents of children with burns: A randomized controlled trial. Burns. 2017 May;43(3):583-591.
Wagner B, Rosenberg N, Hofmann L, Maass U. Web-Based Bereavement Care: A Systematic Review and Meta-Analysis. Front Psychiatry. 2020 Jun 24;11:525.
Lange A, van de Ven JP, Schrieken B, Emmelkamp PM. Interapy, treatment of posttraumatic stress through the Internet: a controlled trial. J Behav Ther Exp Psychiatry. 2001 Jun;32(2):73-90.
Lange A, van de Ven JP, Schrieken B. Interapy: treatment of post-traumatic stress via the internet. Cogn Behav Ther. 2003;32(3):110-24.
Knaevelsrud C, Maercker A. Internet-based treatment for PTSD reduces distress and facilitates the development of a strong therapeutic alliance: a randomized controlled clinical trial. BMC Psychiatry. 2007 Apr 19;7:13.
Knaevelsrud C, Brand J, Lange A, Ruwaard J, Wagner B. Web-based psychotherapy for posttraumatic stress disorder in war-traumatized Arab patients: randomized controlled trial. J Med Internet Res. 2015 Mar 20;17(3):e71.
Beyer JA. The Effects Of Web-Based Interactive Emotional Disclosure On Stress And Health: A Randomized, Controlled Study. Wayne State University Dissertations. 2010;5.
Hirai M, Clum GA. An Internet-based self-change program for traumatic event related fear, distress, and maladaptive coping. J Trauma Stress. 2005 Dec;18(6):631-6.
Hirai M, Skidmore ST, Clum GA, Dolma S. An investigation of the efficacy of online expressive writing for trauma-related psychological distress in Hispanic individuals. Behav Ther. 2012 Dec;43(4):812-24.
Possemato K, Ouimette P, Knowlton P. A brief self-guided telehealth intervention for post-traumatic stress disorder in combat veterans: a pilot study. J Telemed Telecare. 2011;17(5):245-50.
Sayer NA, Noorbaloochi S, Frazier PA, Pennebaker JW, Orazem RJ, Schnurr PP, Murdoch M, Carlson KF, Gravely A, Litz BT. Randomized Controlled Trial of Online Expressive Writing to Address Readjustment Difficulties Among U.S. Afghanistan and Iraq War Veterans. J Trauma Stress. 2015 Oct;28(5):381-90.
Stockton H, Joseph S, Hunt N. Expressive Writing and Posttraumatic Growth: An Internet-Based Pilot Study. Traumatology: An Internation Journal. 2014;20(2):75-83.
Winzelberg AJ, Classen C, Alpers GW, Roberts H, Koopman C, Adams RE, Ernst H, Dev P, Taylor CB. Evaluation of an internet support group for women with primary breast cancer. Cancer. 2003 Mar 1;97(5):1164-73.
Cox CM, Kenardy JA, Hendrikz JK. A randomized controlled trial of a web-based early intervention for children and their parents following unintentional injury. J Pediatr Psychol. 2010 Jul;35(6):581-92.
Ford-Gilboe M, Varcoe C, Scott-Storey K, Perrin N, Wuest J, Wathen CN, Case J, Glass N. Longitudinal impacts of an online safety and health intervention for women experiencing intimate partner violence: randomized controlled trial. BMC Public Health. 2020 Feb 26;20(1):260.
Owen JE, Klapow JC, Roth DL, Shuster JL Jr, Bellis J, Meredith R, Tucker DC. Randomized pilot of a self-guided internet coping group for women with early-stage breast cancer. Ann Behav Med. 2005 Aug;30(1):54-64.
Slade P, West H, Thomson G, Lane S, Spiby H, Edwards RT, Charles JM, Garrett C, Flanagan B, Treadwell M, Hayden E, Weeks A. STRAWB2 (Stress and Wellbeing After Childbirth): a randomised controlled trial of targeted self-help materials to prevent post-traumatic stress disorder following childbirth. BJOG. 2020 Jun;127(7):886-896.
Steinmetz SE, Benight CC, Bishop SL, James LE. My Disaster Recovery: a pilot randomized controlled trial of an Internet intervention. Anxiety Stress Coping. 2012;25(5):593-600.
van Rosmalen-Nooijens K, Lo Fo Wong S, Prins J, Lagro-Janssen T. Young People, Adult Worries: Randomized Controlled Trial and Feasibility Study of the Internet-Based Self-Support Method "Feel the ViBe" for Adolescents and Young Adults Exposed to Family Violence. J Med Internet Res. 2017 Jun 12;19(6):e204.
Bomyea J, Stein MB, Lang AJ. Interference control training for PTSD: A randomized controlled trial of a novel computer-based intervention. J Anxiety Disord. 2015 Aug;34:33-42.
Fonzo GA, Fine NB, Wright RN, Achituv M, Zaiko YV, Merin O, Shalev AY, Etkin A. Internet-delivered computerized cognitive & affective remediation training for the treatment of acute and chronic posttraumatic stress disorder: Two randomized clinical trials. J Psychiatr Res. 2019 Aug;115:82-89.
Iyadurai L, Blackwell SE, Meiser-Stedman R, Watson PC, Bonsall MB, Geddes JR, Nobre AC, Holmes EA. Preventing intrusive memories after trauma via a brief intervention involving Tetris computer game play in the emergency department: a proof-of-concept randomized controlled trial. Mol Psychiatry. 2018 Mar;23(3):674-682.
Kassam-Adams N, Marsac ML, Kohser KL, Kenardy J, March S, Winston FK. Pilot Randomized Controlled Trial of a Novel Web-Based Intervention to Prevent Posttraumatic Stress in Children Following Medical Events. J Pediatr Psychol. 2016 Jan-Feb;41(1):138-48.
Larsen SE, Lotfi S, Bennett KP, Larson CL, Dean-Bernhoft C, Lee HJ. A pilot randomized trial of a dual n-back emotional working memory training program for veterans with elevated PTSD symptoms. Psychiatry Res. 2019 May;275:261-268.
Schoorl M, Putman P, Van Der Does W. Attentional bias modification in posttraumatic stress disorder: a randomized controlled trial. Psychother Psychosom. 2013;82(2):99-105.
Schweizer S, Samimi Z, Hasani J, Moradi A, Mirdoraghi F, Khaleghi M. Improving cognitive control in adolescents with post-traumatic stress disorder (PTSD). Behav Res Ther. 2017 Jun;93:88-94.
Marsac ML, Hildenbrand AK, Kohser KL, Winston FK, Li Y, Kassam-Adams N. Preventing posttraumatic stress following pediatric injury: a randomized controlled trial of a web-based psycho-educational intervention for parents. J Pediatr Psychol. 2013 Nov;38(10):1101-11.
Miner A, Kuhn E, Hoffman JE, Owen JE, Ruzek JI, Taylor CB. Feasibility, acceptability, and potential efficacy of the PTSD Coach app: A pilot randomized controlled trial with community trauma survivors. Psychol Trauma. 2016 May;8(3):384-392.
Zernicke KA, Campbell TS, Speca M, McCabe-Ruff K, Flowers S, Carlson LE. A randomized wait-list controlled trial of feasibility and efficacy of an online mindfulness-based cancer recovery program: the eTherapy for cancer applying mindfulness trial. Psychosom Med. 2014 May;76(4):257-67.
Grasser LR, Javanbakht A. Treatments of Posttraumatic Stress Disorder in Civilian Populations. Curr Psychiatry Rep. 2019 Feb 8;21(2):11.
Jakšić N, Brajković L, Ivezić E, Topić R, Jakovljević M. The role of personality traits in posttraumatic stress disorder (PTSD). Psychiatr Danub. 2012 Sep;24(3):256-66.
Kazdin AE. Mediators and mechanisms of change in psychotherapy research. Annu Rev Clin Psychol. 2007;3:1–27.
Bolton AJ, Dorstyn DS. Telepsychology for Posttraumatic Stress Disorder: A systematic review. J Telemed Telecare. 2015 Jul;21(5):254-67.
Wagner B, Knaevelsrud C, Maercker A. Post-traumatic growth and optimism as outcomes of an internet-based intervention for complicated grief. Cogn Behav Ther. 2007;36(3):156-61.
Nieminen K, Berg I, Frankenstein K, Viita L, Larsson K, Persson U, Spånberger L, Wretman A, Silfvernagel K, Andersson G, Wijma K. Internet-provided cognitive behaviour therapy of posttraumatic stress symptoms following childbirth-a randomized controlled trial. Cogn Behav Ther. 2016 Jun;45(4):287-306.
DOI: http://dx.doi.org/10.26549/jams.v9i1.39105
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