百草枯中毒致肺纤维化机制与治疗研究进展

国昌 袁(华中科技大学同济医学院附属协和医院急诊医学科，湖北武汉)
劲农 张(华中科技大学同济医学院附属协和医院急诊医学科，湖北武汉)

摘要

百草枯(PQ)中毒是临床最常见的急诊中毒症之一，由于PQ聚集于肺脏的特点，PQ中毒造成的肺损伤包括肺纤维化是导致PQ中毒致残或致死的重要原因。本文综述了PQ中毒引起肺纤维化的机制与治疗现状。发病机制包括肺泡损伤、氧化应激、炎性反应、基因表达异常和细胞外基质累积等，治疗策略的重点在于减少毒物吸收，采用激素及免疫抑制剂、抗氧化药物、骨髓间充质干细胞、雌激素等。未来针对PQ的特异性抗体研究可成为治疗PQ的热点之一。

关键词

百草枯；中毒；肺纤维化；机制；治疗

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v5i1.10184