基质金属蛋白酶与心血管疾病相关性研究进展

晓杰 王(承德医学院附属医院，中国)
楚中 汤(承德医学院附属医院，中国)
增斌 冯(承德医学院附属医院，中国)

摘要

基质金属蛋白酶（Matrix metalloproteinases，MMPs）是一类可以分解细胞外基质（Extracellular matrix，ECM）和沉积细胞外基质中的结构蛋白的内肽酶。在心血管疾病的研究中发现MMPs与高血压、动脉粥样硬化、动脉瘤、血管壁重构等疾病的发生、发展密切相关。论文围绕MMPs与心血管疾病的发生、发展相关性以及作用机制和其抑制剂的临床价值作一综述，为心血管疾病的预防和治疗提供依据。

关键词

基质金属蛋白酶（MMPs）；基质金属蛋白酶抑制剂（tissue inhibitor of metalloproteinase，TIMPs）；冠心病；动脉粥样硬化；动脉瘤

参考

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v5i2.11300