联合检测 CK7、CK20、TP53 基因、GATA3、Ki-67 在输尿管肿瘤的表达及指导意义

宝兴 朱(承德医学院附属医院，中国)
新颖 王(承德医学院附属医院，中国)
志勇 王(承德医学院附属医院，中国)

摘要

输尿管肿瘤（ ureteral tumor）在临床上较为罕见，而近年来，检测水平的提升和膀胱癌生存率的改善使其比例逐步上升。它的病理类型与肾盂癌相似，主要为尿路上皮癌（移行细胞癌），因此常被统称为上尿路上皮癌（ UTUC）。以往研究仅关注个别或部分的标志物，但缺乏对其进行综合和全面的分析，无法准确预测疾病过程和预后。为此，我们整理了CK7、CK20、 TP53基因、 GATA3及Ki-67在输尿管肿瘤的表达情况及其作用，以期了解这些分子标记物的联合表达与输尿管肿瘤生物学属性之间的关联。

关键词

输尿管肿瘤； CK7； CK20； GATA3； TP53； Ki-67

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v6i12.14906