长链脂酰辅酶A合成酶1、3在冠心病中的研究进展

佳彬 宋(承德医学院附属医院，中国)
爱文 张(承德医学院附属医院，中国)

摘要

长链脂酰辅酶A合成酶家族（ACSLs）是脂肪酸代谢途径中至关重要的酶，包含五个成员，分别为ACSL1、3、4、5和6。其中ACSL1、ACSL3与人体冠状动脉性心脏病息息相关。ACSL1、ACSL3通过特异性反应形成衍生物激活链长为12~20个碳原子的脂肪酸，形成酰基辅酶a，参与脂肪酸氧化、修饰细胞膜等生理反应。另外，ACSL1、ACSL3还通过不同的信号通路和分子机制调控细胞凋亡。通过参与脂质代谢、细胞凋亡进程，ACSL1、ACSL3在冠状动脉性心脏病的发生发展中起着重要作用。论文将从定位分布、底物选择、疾病以及其相关分子调控机制进展等方面进行阐述，并对ACSL1、ACSL3研究的意义进行展望。

关键词

长链脂酰辅酶A合成酶1；长链脂酰辅酶A合成酶3；脂肪酸；冠状动脉性心脏病

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i1.15603