微针用于治疗病理性瘢痕的研究进展

鹏云 刁(青海大学附属医院，中国)
献珍 王(青海大学附属医院，中国)

摘要

微针疗法利用刺激胶原蛋白生成和促进皮肤重塑的能力，在治疗瘢痕前景可观。不少研究表明了微针疗法的有效性，尤其是在与其他疗法结合使用时。单独使用微针疗法可以明显改善疤痕的外观，但将微针疗法与富血小板血浆（PRP）结合使用可以提高疗效。这种技术能诱导组织学变化，促进成纤维细胞的活性和胶原蛋白的沉积，这对疤痕愈合至关重要。微针贴片是一种直接向真皮层输送药物的新方法，可有效预防和治疗各种类型的疤痕。虽然微针疗法前景广阔，但在规范治疗方案和解决患者个体反应方面仍存在挑战，论文就微针疗法在治疗病理性瘢痕方面的进展进行综述。

关键词

病理性瘢痕；微针；增生性瘢痕；经皮胶原诱导疗法

参考

Harith Ali Hasan Al-Nauimi, Ahmed Al-Samadi, Ahmed Hisham QASSIM. The Effect of Microneedling on Skin Histology: Review of Literature[J/OL]. Annals of the College of Medecine, 2024,46(1):114-119.

Abdulsalam Mohammed Bin Khalel, Amin Amer, Ayman Youssef. An Overview about Microneedling and its Use in Dermatology: Review Article[J/OL]. The Egyptian Journal of Hospital Medicine, 2022,89(1):4570-4572.

Flávio Barbosa Luz, Tadeu de Rezende Vergueiro. Acne Scar: Microneedling[M/OL]. 2020:677-682.

Qing Zhang, Lin Shi, Hong-Yang He, 等. Down-Regulating Scar Formation by Microneedles Directly via a Mechanical Communication Pathway[J/OL]. ACS Nano, 2022,16(7):10163-10178.

Yihui Huang, Jingwen Li, Yan Lin Wang. Intradermal delivery of an angiotensin II receptor blocker using a personalized microneedle patch for treatment of hypertrophic scars.[J/OL]. Biomaterials Science, 2022,11(2):583-595.

Nisma Mujahid, Faizah Shareef, Mayra B.C. Maymone. Microneedling as a Treatment for Acne Scarring: A Systematic Review[J/OL]. Dermatologic Surgery, 2020,46(1):86-92.

David C. Yeo, Elizabeth R. Balmayor, Jan-Thorsten Schantz. Microneedle physical contact as a therapeutic for abnormal scars[J/OL]. European Journal of Medical Research, 2017,22(1):1-9.

Luciana Gasques de Souza, Michael H. Gold, Denise Steiner. A simple drug-delivery microneedling technique modality successfully improves linear atrophic scars.[J/OL]. Journal of Cosmetic Dermatology, 2023.

Sabry Ghanem, Nashwa K. Radwan, Arwa M. Hassan. Micro needling in treatment of stretch marks[J/OL]. International journal of dermatology, venereology and leprosy sciences, 2023,6(2):17-21.

Yating Yang, Lingling Xia, Xiaoyu Ning. Enhanced Drug Permeation into Human Keloid Tissues by Sonophoresis-Assisted Microneedling.[J/OL]. 2021,6(6):660-666.

Hye Jin Chung, Judy Cheng, Manuel Gonzalez. Factors Affecting Depth of Penetration in Microneedling- and Laser-Assisted Drug Delivery: The Importance of Timing of Topical Application.[J/OL]. Dermatologic Surgery, 2020,46(12).

Sayani Bhattacharyya, Kavitha Hasabavi Kotresh. Microneedles-A new paradigm in transdermal delivery of therapeutic agents[J/OL]. Pharmaceutical Sciences Asia, 2022(5):435-445.

Célia Luiza Petersen Vitello Kalil, Clarissa Prieto Herman Reinehr. Microneedling and Drug Delivery[M/OL]. 2021:55-64.

Quita Lopez. Treatment of Acne Scars with Microneedling and Chemical Reconstruction of Scarred Skin Therapy (CROSS) Using Penol/Croton Oil Combination[J/OL]. Journal of Drugs in Dermatology, 2024,23(6):418-422.

K. A. Novikov. Microneedling opportunities in acne and postacne treatment[J/OL]. Medicinskij alfavit, 2022,1(27):79-80.

Linyu Long, Dang Ji, Cheng Hu. Microneedles for in situ tissue regeneration[J/OL]. Materials today bio, 2023,19:100579-100579.

Xue Liu, R. J. Barresi, Michael S. Kaminer. Utilization of ex vivo tissue model to study skin regeneration following microneedle stimuli[J/OL]. Dental science reports, 2022,12(1).

Jose Eduardo Ulloa Rojas, Vivian Leite de Oliveira, Daniele Ribeiro de Araujo. Silk Fibroin/Poly(vinyl Alcohol) Microneedles as Carriers for the Delivery of Singlet Oxygen Photosensitizers.[J/OL]. ACS Biomaterials Science & Engineering, 2021.

Danyang Chen, Yixuan Zhang, Wei Long, 等. Visible light-driven photodynamic therapy for hypertrophic scars with MOF armored microneedles patch[J/OL]. Frontiers in Chemistry, 2023, 11.

Aunna Pourang, Rohit Kakar. Microneedling + PRP (for Rejuvenation, Acne Scarring)[M/OL]. 2021:41-51.

Kamila Zduńska, Anna Kołodziejczak, Helena Rotsztejn. Is skin microneedling a good alternative method of various skin defects removal[J/OL]. Dermatologic Therapy, 2018,31(6).

Bishara S. Atiyeh, Odette Abou Ghanem, Fadl Chahine. Microneedling: Percutaneous Collagen Induction (PCI) Therapy for Management of Scars and Photoaged Skin-Scientific Evidence and Review of the Literature.[J/OL]. Aesthetic Plastic Surgery, 2021,45(1):296-308.

Hisham Shokeir, Nevien A Sami, Samia Esmat. Clinical and histochemical response to automated microneedling therapy in treatment of traumatic scars[J/OL]. International Journal of Health Sciences (IJHS), 2022:643-650.

Samia Esmat, Hisham Shokeir, Nevien Samy, 等. Automated Microneedling Versus Fractional CO2 Laser in Treatment of Traumatic Scars: A Clinical and Histochemical Study.[J/OL]. Dermatologic Surgery, 2021,47(11):1480-1485.

Zeming Zhuang, Yong Wang, Zi-Xuan Feng. Targeting Diverse Wounds and Scars: Recent Innovative Bio-design of Microneedle Patch for Comprehensive Management.[J/OL]. Small, 2023:e2306565-e2306565.

Mostafa Shehata, Mohamed Mahmoud Elshazly, Shaimaa Bebars. A comparative study of effectiveness of microneedling with and without topical corticosteroids in post-burn hypertrophic scars of face and neck[J/OL]. International Journal of Health Sciences (IJHS), 2022:4141-4153.

Matthias Aust, Desmond Fernandes, Richard Bender. The Value of Medical Needling in Burn Scars[J/OL].2021:22-40.

Katyayani Pandey, Sudha Agrawal, Prajwal Pandey. Efficacy of Autologous Injectable Platelet Rich Fibrin in Facial Atrophic Acne Scars in Combination with Microneedling: A Randomized Clinical Trial[J/OL]. 2024.

Chhaya Kolhal, Rachana Abhijit Laul. Cross technique with 100 % tca versus microneedling with platelet rich plasma in treatment of atrophic acne scars–a comparative study[J/OL]. Global journal for research analysis, 2024.

Moetaz El-Domyati, Noha H. Moftah, Asmaa M. Ahmed. Evaluation of microneedling depth of penetration in management of atrophic acne scars: a split-face comparative study.[J/OL]. International Journal of Dermatology, 2023.

KELLY GRANJA DUARTE DIAS. O uso da técnica de microagulhamento no tratamento de cicatrizes de acne: uma revisão literária[M/OL]. 2024.

Nina Hartman, Jameson Loyal, S. Borsack. Alternating Treatment With Nonablative Fractional Laser and Radiofrequency Microneedling for the Treatment of Acne Scars: A Prospective, Randomized, Split-Face Study.[J/OL]. Dermatologic Surgery, 2023.

E. S. Snarskaya, A. S. Bykanov. Efficacy of transdermal microneedling redermalization with high-molecular-weight hyaluronic acid and sodium succinate in the correction of postacne scars[J/OL]. Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei, 2023.

Andreas Reinke, Eliza Whiteside, Louisa Windus, 等. The advantages of microneedle patches compared to conventional needle-based drug delivery and biopsy devices in medicine[J/OL]. Biomedical engineering advances, 2024:100127-100127.

Waleed Faisal, R. Bamsey. P13 ‘Microneedle’ A new horizon of intradermal therapeutics[J/OL]. British Journal of Dermatology,2024.

Meng Wang, Xiaodan Li, Wenzhen Du. Microneedle-mediated treatment for superficial tumors by combining multiple strategies[J/OL]. Drug Delivery and Translational Research, 2023,13(6):1600-1620.

DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i9.21185