BTG3 在胃癌中的表达及临床病理意义

仁祥 刘(承德医学院附属医院肿瘤科，中国)
东辉 任(承德医学院附属医院肿瘤科，中国)
华川 郑(承德医学院附属医院肿瘤科，中国)

摘要

目的：探讨BTG3在胃癌发生发展中的表达及临床病理意义。方法：利用UALCAN，仙桃和Kaplan-Meier分析BTG3在胃癌的表达及与预后的关系。收集锦州医科大学附属第一医院和神奈川县癌症中心附属医院的肿瘤组织和正常黏膜组织，使用免疫组化检测BTG3蛋白表达，探讨BTG3蛋白表达与胃癌临床病理特征之间的关系。结果：胃癌中BTG3在配对样本和不配对样本中表达均高于正常组织（P＜0.05），BTG3表达与总体生存率和无复发生存期呈负相关。免疫组化显示，BTG3表达在非癌性组织中高于胃癌（P＜0.05）；BTG3在T2-T4，淋巴及静脉侵袭中有更高表达（P＜0.05），但与年龄、性别、淋巴结转移、TNM分期和远处转移不相关（P＞0.05）。结论：BTG3可作为胃癌预后的预测因子，也可作为胃癌基因治疗的潜在靶标。

关键词

BTG3；胃癌；预后；生物信息学

参考

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i9.21201