麻醉药物抑制脓毒症致急性肺损伤中细胞焦亡的研究进展

云霏 鲍(承德医学院附属医院麻醉科，中国)
之皓 冯(承德医学院附属医院麻醉科，中国)
建玲 李(承德医学院附属医院麻醉科，中国)

摘要

近年来，脓毒症发病率和死亡率居高不下，严重危及患者生命，由此引发的急性肺损伤（Acute Lung Injury，ALI）的发病率和死亡率极高。炎症在脓毒症致ALI的病理生理机制中占有一定比重。且近年来与炎症密切相关的细胞焦亡成为研究热点，多数研究证实细胞焦亡与脓毒症致ALI密切相关。对于需要手术干预的脓毒症患者，麻醉是必需的，不同麻醉药物的应用对患者有着不同的影响。研究表明，一些麻醉药物通过抑制细胞焦亡缓解脓毒症致ALI，而当前大多数研究仍是以动物或细胞为主要研究对象，还未进展到临床阶段。

关键词

麻醉药物；脓毒症；细胞焦亡；急性肺损伤

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i9.21203