动静脉内瘘处血管内膜增生的机制研究

悦超 王(承德医学院附属医院肾脏内科，中国)
书众 段(承德医学院附属医院肾脏内科，中国;河北省泛血管疾病重点实验室，中国)

摘要

动静脉内瘘是慢性肾脏病终末期血液透析患者的生命线，动静脉内瘘成熟障碍是维持性血液透析患者面临的重要临床问题，与其预后息息相关。然而具体形成机制尚未完全被揭示，其复杂性和多样性使得目前的研究仍处于不断探索阶段，无法转换为更直接、更有效的治疗措施，进而开发更特异的治疗方法。其中，血管内膜增生是导致动静脉内瘘狭窄和血栓形成的主要原因。论文旨在综述动静脉内瘘成熟障碍的相关病理生理学机制及临床研究进展及治疗方案的新进展，为临床预防与治疗奠定坚实的理论基础。

关键词

动静脉内瘘；血管内膜增生；血管平滑肌

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i10.21649