Wif-1 基因启动子区甲基化在肿瘤中的研究进展

依晗 贾(承德医学院附属医院，中国)
健 陈(承德医学院附属医院，中国)

摘要

Wnt信号通路异常激活和恶性肿瘤的发生发展关系密切，WIF-1基因是Wnt信号通路的抑制因子，能和Wnt蛋白受体直接结合从而抑制Wnt通路的异常激活，从而抑制肿瘤的生长和分化。国内外研究证明，在多种恶性肿瘤中存在WIF-1基因的表达沉默，而这种沉默与WIF-1启动子区域CpG位点的甲基化密切相关，进一步导致WIF-1基因出现低表达，使其无法有效阻断Wnt/β-catenin信号通路的异常激活。论文就目前国内外对Wif-1基因启动子区甲基化在肿瘤中的研究进展作一综述，旨在为疾病的治疗提供更有效的方法。

关键词

Wif-1；DNA甲基化；肿瘤

参考

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i10.21663