幽门螺杆菌与肠易激综合征相关性的研究进展

亚楠 高(保定市第一中心医院，中国)
英霞 郝(保定市第一中心医院，中国)

摘要

肠易激综合征 (Irritable bowel syndrome, IBS) 是一种常见的功能性消化系统疾病，其发病率逐年升高。IBS 是多种因素共同致病的结果，近年来提出 Hp 与 IBS 之间关系密切的研究呈逐年上升趋势，大量文献总结到 Hp 感染可能使 IBS 症状加重。通过论文研究，总结 Hp 引起 IBS 的可能机制为：Hp 感染后通过持续的炎症反应 , 导致肠道粘膜通透性改变；Hp 感染后通过不同途径影响脑 - 肠轴，脑肠肽分泌增加，影响脑 - 肠互动；Hp 感染后机体出现局部及全身免疫反应；Hp 感染后肠道内有害菌群增加，使肠道菌群失调；Hp感染后可通过氧化应激反应影响上述致病过程等。通过这些机制单独或联合作用导致肠道动力异常以及内脏敏感性增高 , 从而使患者表现腹痛、腹泻、便秘等临床症状。

关键词

肠易激综合征；幽门螺杆菌；慢性应激；脑 - 肠互动；肠道菌群；炎症免疫反应；脑肠肽

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DOI: http://dx.doi.org/10.26549/yzlcyxzz.v3i3.3936