研究文章

艾司氯胺酮在外周神经阻滞中的研究进展

摘要

外周神经阻滞是围术期多模式镇痛的关键环节,但单次阻滞时效有限。艾司氯胺酮为氯胺酮 S - 对映异构体,兼具 NMDA 受体拮抗、局麻及抗炎作用,近年被用作局麻药佐剂。本文梳理其在臂丛阻滞、下肢关节周围阻滞及椎旁阻滞中的应用,从机制、效果与安全性展开讨论。现有证据显示其可延长镇痛时长、提升镇痛质量、减少阿片类药物用量,但研究多为单中心小样本、随访偏短,最佳方案尚无共识,仍需高质量研究进一步明确。

关键词

艾司氯胺酮;神经阻滞;局麻药佐剂;术后镇痛;反弹性疼痛

参考

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