研究文章

SPIONs 磁性纳米制剂及其肿瘤诊疗一体化研究进展

摘要

基于超顺磁性铁氧化物纳米颗粒(SPIONs)构建的磁性纳米制剂,是一类外磁场响应型纳米生物平台,可借助外磁场作用实现病灶部位靶向富集,在肿瘤诊疗一体化领域展现出巨大应用潜力。该类制剂拥有良好的生物相容性与可调控的磁学性能,同时便于开展表面功能化修饰,在磁共振成像(MRI)增强、磁热疗、磁粒子成像(MPI)、靶向药物递送等医学领域得到广泛研究。本文系统梳理磁性纳米制剂的材料设计、制备工艺,阐述其肿瘤诊疗的作用机制,总结当前临床转化进展,剖析规模化生产、生物安全性、体内代谢等关键瓶颈,并对未来研究方向进行展望,以期为磁性纳米制剂的基础研究与临床落地提供参考。

关键词

磁性纳米制剂;超顺磁性氧化铁;靶向递送;磁热疗;诊疗一体化;临床转化

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