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探索ZRF1在原发性肝癌组织中的表达及临床意义

玉兰 衣(海军军医大学,转化医学研究中心临床肿瘤研究所,中国)
莎莎 陈(海军军医大学,转化医学研究中心临床肿瘤研究所,中国)
榃伦 曾(海军军医大学,转化医学研究中心临床肿瘤研究所,中国)
喜俊 梁(海军军医大学,转化医学研究中心临床肿瘤研究所,中国)

摘要

目的:研究ZRF1在原发性肝癌患者肿瘤组织中的表达情况,分析其与肝癌患者临床病理特征及预后的相关性。方法:收集243例经术后病理明确诊断为原发性肝癌患者的肿瘤组织样本,通过免疫组织化学法检测原发性肝癌肿瘤组织及相应癌旁组织中ZRF1的表达情况,采用Kaplan Meier生存分析法分析ZRF1的表达水平与原发性肝癌患者预后的相关性。结果:ZRF1在肝癌患者肿瘤组织中的阳性表达率显著低于对应的癌旁组织(P=0.015);此外,ZRF1的表达与年龄、性别、门脉癌栓和肝硬化等临床病例特征均无统计学差异(P>0.05),但与肿瘤大小呈现负相关趋势(P=0.056);最后,在接受索拉非尼治疗的肝癌患者队列中,ZRF1低表达患者的预后显著优于ZRF1高表达的患者(P=0.020)。结论:ZRF1在原发性肝癌肿瘤组织中的表达水平低于其癌旁组织,且ZRF1的表达水平与原发性肝癌患者接受索拉非尼治疗的预后相关,有可能成为原发性肝癌患者接受索拉非尼治疗的疗效预测标志物。

关键词

ZRF1;原发性肝癌;索拉非尼;预后

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参考

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v4i9.8665

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