MicroRNA-155、microRNA-142-5p 在变 应性 鼻炎 中的作用及研究进展

子祎 徐(承德医学院附属医院，中国)
宇丽 张(承德医学院附属医院，中国)

摘要

变应性鼻炎（Allergic rhinitis，AR）是由免疫球蛋白E（immunoglobulin E，IgE）介导的鼻部非感染性炎性疾病，主要临床症状为鼻塞、阵发性喷嚏、清水样涕，可导致睡眠障碍、注意力不集中甚至抑郁，环境污染、气候变化和生活方式等被认为是过敏性疾病发病率增加的原因。尽管对于AR的治疗取得颇大进展，但仍有部分患者的症状未得到足够缓解。因此有必要进一步研究AR的发病机制从而提高AR的诊疗水平。MicroRNA(miRNA）是由18~22个核苷酸组成的短单链非编码RNA，通过结合靶信使RNA（mRNA）上的3'-末端诱导RNA降解或阻断蛋白质合成来调节基因的表达，被认为与炎性疾病、血管疾病、癌症等相关，是国内外学者的研究重点。本文章就与AR密切相关的miRNA研究进展作一简述，希望能对AR诊疗的研究进展提供帮助。

关键词

变应性鼻炎；miRNA；鼻黏膜；诊断和治疗

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v8i1.23395