SphKs/S1P 在哮喘发病机制研究进展

波 王(内蒙古医科大学研究生院，中国;)
少飞 于(内蒙古自治区人民医院儿科，中国;)

摘要

哮喘是一种以慢性气道炎症和气道高反应性为特征的异质性疾病，主要特征包括多种炎症细胞和细胞组分共同参与的气道慢性炎症，引起气道对各种刺激因素呈现高反应性，以及随病程延长而导致的气道重塑。鞘氨醇激酶（Sphingosine kinases，SphKs）是1-磷酸鞘氨醇(sphingosine-1-phosphate,S1P)生成的关键酶。S1P特异性结合S1P受体（sphingosine-1-phosphate receptos,S1PRs)，通过多条途径参与炎症及组织损伤的调控及进展，与疾病的严重程度及预后密切相关。近年来关于SphKs/S1P信号通路在哮喘发生发展的研究逐渐增多，本文就其结构、功能及在哮喘发病可能机制进行综述。

关键词

鞘氨醇激酶；1-磷酸鞘氨醇；哮喘；气道炎症；气道高反应性；气道重塑

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v8i1.23407