甲状 腺癌 COX-2、VEGF、CD163 表达 与分 期、 病理、转移及预后关系研究

娜尔 阿(深圳市宝安区松岗人民医院，甲状腺乳腺外科，中国)
美艳 陈(深圳市宝安区松岗人民医院，甲状腺乳腺外科，中国)
云宏 刘(深圳市宝安区松岗人民医院，甲状腺乳腺外科，中国)
少华 程(深圳市宝安区松岗人民医院，甲状腺乳腺外科，中国)

摘要

本研究旨在探讨甲状腺癌患者组织中COX-2、VEGF、CD163表达与疾病进展及预后的相关性。方法选取2023年7月至2024年12月收治的85例 TC 患者的手术标本，通过免疫组化（IHC）检测肿瘤组织中生物标志物的表达水平。并整合临床病理参数进行生存分析。结果表明：COX-2、VEGF、CD163在TC组织中的表达水平与淋巴结转移、包膜侵犯及预后密切相关。生存分析显示三者高表达患者的无病生存率及总生存率均显著降低。多因素分析表明，COX-2、VEGF、CD163三者联合表达可作为独立预后因素。本研究为甲状腺癌的预后评估及个体化治疗策略的制定提供了新的思路和理论支持。

关键词

甲状腺癌；COX-2；VEGF；CD163；淋巴结转移

参考

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v8i2.23995