生物医用可降解镁合金材料研究现况

泽东 万(承德医学院附属医院，中国)
宇 金(承德医学院附属医院，中国)

摘要

生物医用可降解镁合金材料，由于其具有较好的生物相容性、人体骨组织相似的生物力学性能和可降解性，使其在医疗植入材料领域表现出巨大的发展潜力和可能性。然而，镁合金的解速率过快和产生氢气造成局部气肿等问题仍是其临床应用的主要挑战。目前国内外研究者通过对镁合金进行合金化和表面改性，降低镁合金的降解速率和提高其力学性能。本文就生物医用镁合金材料的特性以及目前相关研究的进展和面临的主要问题和挑战进行综述。

关键词

生物医用金属材料；可降解合金材料；镁基植入物；镁合金

参考

董亮, 何星. 生物医用材料的研究进展及发展前景[J]. 世界复合医学, 2015, 1(4): 340-342.

MACÍAS RUIZ M D C, CUENCA BERMEJO L, VERONESE N, 等. Magnesium in Kidney Function and Disease-Implications for Aging and Sex-A Narrative Review[J]. Nutrients, 2023, 15(7): 1710.

MP S, AM P, J H, et al. Magnesium and its alloys as orthopedic biomaterials: a review[J/OL]. Biomaterials, 2006, 27(9)[2025-01-18].

张家振. 骨植入用高压扭转ZXJ310镁合金组织优化及生物医学特性研究[D/OL]. 北京有色金属研究总院, 2024[2025-01-16].

储茂然, 刘娟, 修朝博, 等. 新型镁合金黏膜刺激性、急性全身毒性及抗菌性能研究[J]. 口腔医学, 2023, 43(10): 878-882.

YC W, MW H, WT W, et al. A novel biodegradable magnesium skin staple: A safety and functional evaluation[J/OL]. Asian journal of Surgery, 2024, 47(7)[2025-01-16].

T O. Magnesium and bone strength[J/OL]. Nutrition (Burbank, Los Angeles County, Calif.), 2001, 17(7-8)[2025-01-18].

信运昌. 医用镁合金在生理环境中降解机理及其表面改性研究[D/OL]. 清华大学, 2011[2025-01-16].

尹林, 黄华, 袁广银, 等. 可降解镁合金临床应用的最新研究进展[J]. 中国材料进展, 2019, 38(2): 126-137.

ISTRATE B, COJOCARU F-D, HENEA M-E, et al. In Vitro and In Vivo Analysis of the Mg-Ca-Zn Biodegradable Alloys[J]. Journal of Functional Biomaterials, 2024, 15(6): 166.

V L, O S, NG S, et al. Mg-Zn-Ca Alloy (ZX00) Screws Are Resorbed at a Mean of 2.5 Years After Medial Malleolar Fracture Fixation: Follow-up of a First-in-humans Application and Insights From a Sheep Model[J/OL]. Clinical orthopaedics and related Research, 2024, 482(1)[2024-12-29].

TIE D, HORT N, CHEN M, et al. In vivo urinary compatibility of Mg-Sr-Ag alloy in swine model[J]. Bioactive Materials, 2022, 7: 254-262.

ABOUTALEBIANARAKI N, ZEBLISKY P, SARKER M D, et al. An osteogenic magnesium alloy with improved corrosion resistance, antibacterial, and mechanical properties for orthopedic applications[J]. Journal of Biomedical Materials Research. Part A, 2023, 111(4): 556-574.

TONG P, CHEN L, SUN X, et al. Surface modification of biodegradable magnesium alloy with poly (L-lactic acid) and sulfonated hyaluronic acid nanoparticles for cardiovascular application[J]. International Journal of Biological Macromolecules, 2023, 237: 124191.

S P, H L, HE K, et al. Bifunctional poly (l-lactic acid)/hydrophobic silica nanocomposite layer coated on magnesium stents for enhancing corrosion resistance and endothelial cell responses[J/OL]. Materials science & engineering. C, Materials for biological Applications, 2021, 127[2024-12-29].

ZARTNER P, CESNJEVAR R, SINGER H, et al. First successful implantation of a biodegradable metal stent into the left pulmonary artery of a preterm baby[J]. Catheterization and Cardiovascular Interventions, 2005, 66(4): 590-594.

WAKSMAN R, ERBEL R, DI MARIO C, et al. Early- and long-term intravascular ultrasound and angiographic findings after bioabsorbable magnesium stent implantation in human coronary arteries[J]. JACC. Cardiovascular Interventions, 2009, 2(4): 312-320.

DOI: http://dx.doi.org/10.12345/yzlcyxzz.v8i2.24002