miRNA 在周围神经再生中的研究进展

鹏飞 杜(承德医学院附属医院，中国)
野 袁(承德医学院附属医院，中国)
赛赛 杜(承德医学院附属医院，中国)
培 王(承德医学院附属医院，中国)

摘要

miRNA是一种小型非编码 RNA，通过调控 mRNA 的降解或翻译抑制来影响基因表达。近年来研究表明，miRNA 在周围神经损伤修复中的生物学过程中发挥了关键作用。在这篇综述中，我们汇总了 miRNA 在周围神经再生中的作用机制，特别是其在神经元存活、轴突再生、雪旺细胞功能及免疫调控中的多重作用，通过 miRNA 介导的分子调控网络，并分析了其潜在的治疗应用前景，同时指出未来研究方向，包括优化miRNA递送系统和探索联合疗法，以进一步推动其在神经损伤修复中的应用。

关键词

MicroRNA；周围神经损伤；轴突再生；炎症反应；雪旺细胞；基因调控；治疗策略

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v8i2.24015