CHIT1 对中枢神经系统疾病作用的研究进展

瑶 刘(承德医学院附属医院，中国)
晓璇 张(承德医学院附属医院，中国)
感恩 王(承德医学院附属医院，中国)
冰纯 李(承德医学院附属医院，中国)

摘要

几丁质酶1（CHIT1）近年来被证实在中枢神经系统（CNS）疾病中发挥关键调控作用，其功能涵盖神经炎症调节、病理蛋白清除及组织动态重塑等多个层面。在肌萎缩侧索硬化（ALS）中，CHIT1作为小胶质细胞活化标志物，通过脑脊液水平与疾病进展呈显著正相关；在多发性硬化（MS）中，其参与髓鞘碎片吞噬清除，与远期残疾进展及治疗反应密切相关；在阿尔茨海默病（AD）中，CHIT1能够抑制炎症反应、增强β-淀粉样蛋白清除，并维持溶酶体稳态；在缺血性脑血管病中，CHIT1具有早期抗炎保护与晚期促纤维化的双重角色。未来需通过进一步研究阐明其在疾病不同阶段的作用，为神经退行性疾病和脑血管病诊疗提供新方向。

关键词

几丁质酶1；中枢神经系统疾病；神经炎症；分子机制

参考

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v8i2.24018