血管性血友病因子及其裂解酶与脑小血管病的研究进展

丽丽 刘(承德医学院附属医院，中国)
志杰 窦(承德医学院附属医院，中国)

摘要

CSVD是严重威胁我国民众健康的常见病症，它通常起病隐匿，其常见的发病机制包含慢性脑缺血与低灌注、内皮功能障碍、组织间液回流受阻、血脑屏障受损、炎症反应等；而且以上机制之间还存在相互影响的关系。VWF在血栓形成和炎症细胞募集中起重要作用。其裂解酶ADAMTS13通过裂解超大分子量VWF，以此减少血栓形成及炎症募集。故研究调节VWF水平或增强其裂解酶ADAMTS13活性为靶点的治疗策略在脑小血管病治疗或许将成为热门，本文将对其机制进行综述。

关键词

脑小血管病；血管性血友病因子；血管性血友病因子裂解蛋白酶；血栓形成；炎症

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v8i2.24023