探讨 HPV 感染患者分别应用重组人干扰素 α-2b 凝胶和宫颈癌栓治疗的疗效研究

菲菲 刘(河北省承德市第三医院妇瘤科，中国)
东辉 任(河北省承德市第三医院妇瘤科，中国)
鸿楠 金(河北省承德市第三医院妇瘤科，中国)
燕 张(河北省承德市第三医院妇瘤科，中国)

摘要

本研究通过随机对照试验，探讨重组人干扰素α-2b凝胶与宫颈癌栓单用及联合方案对高危型HPV感染患者的治疗效应。研究纳入150例病例，采用随机数字表法分为三组：A组（n=50）接受干扰素凝胶治疗，B组（n=50）使用宫颈癌栓，联合组（n=50）采用双药联合方案，疗程均为3个月。实验数据表明，联合治疗组在临床总有效率方面显著优于单药组（P<0.05），具体表现为HPV-DNA拷贝数显著下降，Th1型细胞因子（IL-2、IFN-γ）水平上调，Th2型细胞因子（IL-4、IL-10）水平下调，同时T淋巴细胞亚群（CD4+/CD8+）比值明显改善（P<0.05）。研究证实，联合治疗方案可通过协同作用机制，有效增强抗病毒效应及免疫调节功能，其临床疗效显著优于单一药物治疗方案。

关键词

HPV；重组人干扰素α-2b凝胶；宫颈癌

参考

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v8i2.24028