Novel Approaches in Respiratory Physiology Research: Insights into Lung Function and Disease Mechanisms

Simona Gill(.Department of Internal Medicine, Veterans Affairs Clinical Epidemiology Research Center, West Haven, Connecticut)
Mariana Brandas(Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho Centro de Ciências da Saúde , Laboratório de Investigação Pulmonar, Rio de Janeiro, Rio de Janeiro, Brazil)
R. M. Ghand(Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho Centro de Ciências da Saúde , Laboratório de Investigação Pulmonar, Rio de Janeiro, Rio de Janeiro, Brazil)

Abstract

Respiratory physiology research has undergone significant advancements in recent years, offering novel insights into lung function and the underlying mechanisms of respiratory diseases. This paper explores emerging approaches in respiratory physiology research aimed at uncovering the intricacies of lung function and disease pathogenesis. Utilizing cutting-edge techniques and methodologies, researchers have delved into the cellular and molecular mechanisms governing respiratory processes, shedding light on both normal physiological functions and aberrant disease states. Key areas of investigation include airway mechanics, gas exchange dynamics, pulmonary vascular regulation, and immune responses within the respiratory system. Through a comprehensive review of recent literature, this paper synthesizes findings from studies employing diverse experimental models, ranging from cellular and animal models to human clinical studies. Insights gleaned from these investigations have provided a deeper understanding of respiratory physiology and identified potential targets for therapeutic intervention in respiratory diseases. Furthermore, advancements in imaging modalities, omics technologies, and computational modeling have enabled researchers to elucidate complex interactions within the respiratory system with unprecedented precision and detail.

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DOI: http://dx.doi.org/10.26549/ahpr.v5i2.15930