Comparative Study on the Correction of Lipemia Interference in Complete Blood Count

Lirong He(Pingshan District People's Hospital of Shenzhen)

Abstract

Background: Lipemia, characterized by elevated triglyceride levels in blood samples, is a prevalent preanalytical interferent in clinical hematology. It leads to erroneous measurements of key complete blood count (CBC) parameters, including falsely elevated hemoglobin (Hgb) and platelet (PLT) counts. These inaccuracies can compromise diagnostic reliability and patient management.Objective: This review systematically evaluates existing correction methods for lipemic interference in CBC analysis, comparing their efficacy, limitations, and applicability in clinical settings.Methods: We analyze saline replacement, formula-based correction, instrument-specific algorithms, and emerging technologies, supported by experimental and clinical validation data.Conclusion: An optimized, context-dependent strategy is proposed, integrating multiple correction approaches based on lipemia severity. Future research directions, including artificial intelligence (AI)-enhanced corrections and standardized protocols, are discussed to advance hematology testing accuracy.

Keywords

Lipemic samples; Hemoglobin interference; Platelet counting; Correction methods; Hematology analyzers; Optimization strategies

References

JIA Xiaobin, Wang Cong. Comparison of the application value of automatic blood cell analyzer and blood smear cell morphology in blood routine examination [J]. Wisdom and Health, 2012,8(16):9-12.

Wu Xing. Comparison of accuracy of RBC and Hb levels in blood routine examination by different blood collection methods [J]. Journal of Shanxi Health Vocational College,2022,32(02):27-29.

Li Li, Huang He, Hong Yanying. Effect of highly valent cold agglutinin combined with cryoglobulin on blood routine test results and its correction method [J]. Marker Immunoassay and Clinical Analysis,20,27(10):1750-1755.

Lu Yingjie, Xu Qianqian, Jiang Wangqing, et al. The value of MCHC in detecting and correcting the results of blood routine analysis [J]. Laboratory Medicine,202,37(08):754-756. (in Chinese)

Wang Ying, Shan Hongli, Qu Linlin. Study on the value of blood routine MCHC in indicating abnormal character of specimens and anti-interference scheme [J]. International Journal of Laboratory Medicine,202,43(03):285-289.

DOI: http://dx.doi.org/10.26549/jams.v8i1.24435