Predictive Value of Combined Urinary Sodium, Urinary Fek, and Urinary Uk/Ucr Tests in Sepsis-Induced Early Acute Kidney Injury

Yu Wang(North China Hospital of Traditional Chinese Medicine)
Ruan Chao(North China Hospital of Traditional Chinese Medicine)
Xiaoyi Miao(North China Hospital of Traditional Chinese Medicine)
Bing Li(North China Hospital of Traditional Chinese Medicine)
Wenlu Ma(North China Hospital of Traditional Chinese Medicine)

Abstract

Objective: To explore the predictive value of the combined test of urinary sodium, urinary potassium excretion fraction (FEK), and urinary potassium concentration/urine creatinine concentration (UK/UCr) in sepsis-induced early acute kidney injury (AKI). Methods: Sixty sepsis patients admitted to the Northern Hospital of National Pharmaceuticals from 2022.4 to 2024.4 were selected and divided into the AKI group (n=21) and the non-AKI group (n=39) according to whether AKI occurred or not, and another 20 health check-up subjects from our hospital were selected to be included in the control group during the same period of time, and we compared the urinary sodium, urinary FEK, and urinary UK/UCr tests of the three groups, and analysed the urinary potassium concentration/urine creatinine concentration (UK/UCr) in the early stage of sepsis-induced acute kidney injury (AKI) by plotting the working characteristics of the subjects ( ROC) curve graph to analyse the predictive value of the combined detection of urinary sodium, urinary FEK and urinary UK/UCr in sepsis-induced early AKI. Results: The levels of urinary FEK and urinary UK/UCr in the non-AKI group were higher than those in the control group, and the levels of urinary sodium were lower than those in the control group (P < 0.05), while the levels of urinary FEK and urinary UK/UCr in the AKI group were higher than those in the non-AKI group, and the levels of urinary sodium were lower than those in the non-AKI group (P < 0.05); the ROC was plotted and found that the combined test of urinary sodium, urinary FEK, and urinary UK/UCr was useful for the prediction of early AKI caused by sepsis. The area under the curve (AUC) values ranged from 0.694-0.940, with high sensitivity and specificity, and the value of predicting sepsis-induced early AKI was high. Conclusion: Urinary sodium, urinary FEK and urinary UK/UCr can be used as effective biomarkers for the early prediction of AKI, and the combined test has high value in predicting early AKI caused by sepsis.

Keywords

urinary sodium; urinary potassium excretion fraction; urinary potassium concentration/urine creatinine concentration; sepsis

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DOI: http://dx.doi.org/10.26549/jams.v8i1.26483