Chemical Constituents of Salvia nanchuanensis and Their Biological Evaluation

Deng Mengling(Sichuan University)
Zhou Pengjun(Sichuan University)
Cheng Chunru(Sichuan University)

Abstract

A comprehensive phytochemical investigation of Salvia nanchuanensis, an endemic medicinal plant in China, was carried out to explore its chemical constituents. As a result, nine compounds were isolated from the acetone extract of the whole plant. These compounds include lignans, sterols, phenolic acids and other constituents,  and were identified as clemaphenol A (1), (-)-syringaresinol (2), (+)-epipinoresinol (3),  6α-hydroxystigmast-4-en-3-one (4), 6β-hydroxystigmast-4-en-3-one (5), β-sitosterol (6), terephthalic acid bis (2-ethyl-hexyl) ester (7), antiarol (8), and 8-hydroxycarvacrol (9). Among them, compound 6 exhibited protective effects against cancer cachexia-induced myotube atrophy. These findings indicate that S. nanchuanensis represents a valuable source of natural products with potential relevance for cachexia-related research.

Keywords

Keywords:Salvia nanchuanensis; phytochemical investigation; chemical constituents; lignans; sterols; β-sitosterol; cancer cachexia; myotube atrophy

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DOI: http://dx.doi.org/10.26549/jams.v9i1.36931