Insights into the Molecular Mechanisms of Insulin Resistance and Type 2 Diabetes

John A. Smith Smith(University of California, San Francisco (UCSF), San Francisco, United States)
Jane Doe(University of California, San Francisco (UCSF), San Francisco, United States)

Abstract

In this study, we employ a combination of in vitro and in vivo models to explore the molecular underpinnings of insulin resistance and type 2 diabetes. We conduct thorough analyses of insulin signaling pathways, glucose uptake, and metabolic regulation in both cellular and animal models. By identifying the key molecular defects contributing to insulin resistance, we can develop targeted therapeutic strategies to reverse or mitigate the effects of these defects. Our findings suggest that targeting specific points in the insulin signaling cascade, such as IRS activation and Akt phosphorylation, may represent effective strategies for treating insulin resistance and type 2 diabetes. Furthermore, interventions that modulate inflammation, oxidative stress, and mitochondrial function may also prove beneficial. Overall, this research provides critical insights into the complex molecular mechanisms of insulin resistance and type 2 diabetes, paving the way for novel therapeutic approaches to combat this global health concern.

References

Writing, A. S., & stock, M. J. (1994). Insulin resistance: a major pathogenic factor in the polygenic disease syndrome of maturity-onset diabetes mellitus. Diabetologia, 37(12), 1302-1308.

Barroso, I., &FLOWER, D. J. (2004). Insulin resistance: the pivotal role of muscle metabolism. Nature Medicine, 10(9), 985-991.

Vessby, B., &estedt, B. (1993). Insulin resistance in the pathogenesis of non-insulin-dependent diabetes mellitus. Diabetes Care, 16(3), 460-464.

Progress in understanding the pathogenesis of type 2 diabetes. (2001). Nature Genetics, 29(6), 635-643.

printz, M., & bergman, R. N. (2003). Insulin action, resistance, and mimetics. Annual Review of Pharmacology and Toxicology, 43, 15-33.

flexner, S. J., &flexner, E. M. (2002). Insulin resistance: the primary defect in type 2 diabetes. The Endocrinologist, 12(6), 397-403.

wei, Y., & zhang, P. (2015). Insulin resistance and type 2 diabetes: pathogenesis and therapeutic strategies. International Journal of Endocrinology, 2015, 781210.

flexner, S. J. (2003). Insulin resistance: the primary defect in type 2 diabetes. The Endocrinologist, 13(1), 34-39.

Barzilai, N., & Spiegelman, D. (1995). The insulin resistance syndrome: a multifaceted approach to a multifaceted disease. Diabetes Care, 18(3), 447-453.

flexner, S. J. (2002). Insulin resistance: the primary defect in type 2 diabetes. The Endocrinologist, 12(6), 397-403.

DOI: http://dx.doi.org/10.26549/jer.v5i1.15953