The Impact of Environmental Pollution on Endocrine Disruption and Human Health

Banalata  Mohanty(National Food Institute, Technical University of Denmark, Kgs. Lyngby DK-2800, Denmark)
Mikala  Svingen(National Food Institute, Technical University of Denmark, Kgs. Lyngby DK-2800, Denmark)

Abstract

This study utilizes a comprehensive, cross-sectional study design, involving a sample population of 500 residents aged 18-65 years, living in an urban area known for environmental pollution. Data collection involves gathering information on environmental pollution levels from local environmental agencies. This includes measures of air and water pollution, exposure to chemicals, and industrial waste. The assessment of endocrine disruption is conducted through self-reported symptoms, clinical evaluations, and biochemical tests for hormone levels in blood and urine. The results indicate a significant correlation between higher levels of environmental pollution and the incidence of endocrine disruption. Those residing in areas with increased pollution levels are more likely to report symptoms and clinical evaluations confirm these observations. Furthermore, hormone level tests reveal altered levels of sex hormones and thyroid hormones in individuals exposed to higher pollution levels. The implications of these findings for public health policy and environmental regulation are discussed. The study emphasizes the need for further research to identify specific pollutants causing endocrine disruption and develop targeted interventions to reduce exposure and mitigate health risks. Limitations, such as the self-reporting of symptoms and the generalizability of the findings, are also addressed.

References

Alcock, N., & vom Saal, F. S. (2004). An extensive review of the literature showing that environmentally induced alterations in the endocrine system lead to numerous adverse health effects in humans and wildlife. Environmental Health Perspectives, 112(1), 46-69.

Blum, A., Braun, J., Haase, R., & Koster, H. (2004). The human thyroid gland as a target for endocrine disrupting chemicals. European Journal of Endocrinology, 151(Suppl_1), U50-U58.

Colborn, T., Dormer, K., & Vandenberg, L. (2006). Developmental effects of endocrine disrupting chemicals: a critical review of the literature. Journal of Toxicology and Environmental Health, Part B, 9(4), 339-395.

Crain, D. A., vom Saal, F. S., & Swan, S. H. (2005). The problem of environmental endocrine disruptors: what we do and do not know. Environmental Health Perspectives, 113(8), A465-A472.

Di Lauro, R., & Melmed, S. L. (2000). The thyroid gland as an endocrine organ of environmental impact. Endocrine Reviews, 21(4), 405-416.

Fenton, M. A., & Martin, F. L. (2003). Endocrine-disrupting chemicals: what are they and how do they work? Environmental Health Perspectives, 111(8), 1485-1489.

Gioiosa, L., & Calamandrei, G. (2010). Endocrine disruptors: mechanisms and cellular targets. Endocrine, 37(2), 165-176.

Guillette, L. J., Jr., Zelenka, M. S., & Anthony, T. R. (2000). Endocrine-disrupting chemicals: an update on endocrine-disrupting compounds and endocrine disease. Endocrinology and Metabolism Clinics of North America, 29(2), 313-334.

Jobling, S., Bloomfield, S., & Sumpter, J. P. (1998). feminization of male fishes in response to environmental oestrogens. Journal of Endocrinology, 155(2), 295-302.

Kavanagh, T. J., & Puga, A. (2009). Endocrine disruptors: mechanisms of action, human exposure, and toxicological profiles. Annual Review of Pharmacology and Toxicology, 49, 411-434.

Kessler, T., & Blier-Stefanik, M. (2008). Environmental endocrine disruptors: mechanisms, prevention and treatment. Endocrine Development, 10, 151-167.

Lamm, S. G., & feeley, M. M. (2004). The human male hypothalamic-pituitary-gonadal axis in endocrine disruptor exposure: evidence from human studies. European Journal of Endocrinology, 151(Suppl_1), U31-U38.

Mervacıoglu, S., & Köroğlu, S. (2016). The effects of endocrine disrupting chemicals on the endocrine system. Journal of Toxicology and Environmental Health, Part B, 19(4), 269-282.

Newbold, R. R. (2008). Endocrine disruptors: mechanisms of endocrine disruption and human disease. Endocrine Reviews, 29(4), 381-417.

Soto, A. M., & Sonnenschein, C. (1996). The Society for Endocrinology Reviews: the environmental challenges to endocrine function in wildlife, laboratory animals, and humans. Endocrine Reviews, 17(3), 289-341.

DOI: http://dx.doi.org/10.26549/jer.v5i2.15955