Molecular Basis of Puberty Initiation and Hormonal Control

Seongsoon  Mun(Department of Transfusion Medicine, Tata Medical Center, Newtown, Rajarhat, Kolkata, India)
JiSeon x JiSeon Park(Department of Transfusion Medicine, Tata Medical Center, Newtown, Rajarhat, Kolkata, India)

Abstract

Puberty is a pivotal transition in human development, marked by profound morphological and endocrine changes. Understanding the molecular underpinnings and hormonal regulation of puberty initiation is crucial for deciphering the complex interplay between genetics, environment, and endocrinology. This research article meticulously examines the molecular mechanisms that orchestrate the onset of puberty. Utilizing advanced cellular and molecular biology techniques, we identify and characterize the key players, such as transcription factors, signaling molecules, and regulatory genes, that are pivotal in triggering puberty. We also investigate the pivotal role of hormones, including GnRH, LH, FSH, and sex steroids, in regulating the expression and function of these molecular determinants. Through comprehensive gene expression analysis, protein phosphorylation studies, and animal model experiments, we delve into the intricate signaling cascades that modulate the timing of puberty. Our findings not only advance our understanding of the fundamental mechanisms governing puberty initiation but also provide valuable insights into the potential implications for clinical practice, including the diagnosis and management of pubertal disorders and the optimization of pubertal timing for individual health and development.

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DOI: http://dx.doi.org/10.26549/jer.v5i2.15956