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EGFR-TP53 共突变晚期非小细胞肺癌研究进展

秀荣 包(内蒙古医科大学附属医院,中国)
俊珍 高(内蒙古医科大学附属医院,中国)

摘要

肺癌相关死亡率逐年上升,目前靶向药物EGFR-酪氨酸激酶抑制剂(TKI)已被国内外权威指南推荐作为EGFR敏感突变非小细胞肺癌患者的一线治疗药物,显著提高了肺癌患者的生存期。尽管如此,原发性或获得性耐药导致治疗中止和疾病进展。TP53突变是NSCLC中最常见的突变,既往多项研究已经证实TP53突变在靶向治疗反应方面的作用,论文就TP53突变在原发性和获得性EGFR-TKI耐药中的作用及其可能的机制,在预测EGFR-TKI靶向治疗反应中的作用,以及近年来EGFR-TP53共突变非小细胞肺癌患者治疗研究进展进行综述。

关键词

非小细胞肺癌;TP53突变;靶向治疗;耐药机制

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参考

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DOI: http://dx.doi.org/10.26549/nrr.v3i2.17965

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