含I型血小板结合蛋白基序的解聚蛋白样金属蛋白酶-5的研究进展

拓 杨(承德医学院附属医院心血管内科，中国)
虹 王(承德医学院附属医院心血管内科，中国)
立杰 柴(承德医学院附属医院心血管内科，中国)

摘要

Adamts5是ADAMTSs家族中的一员，该家族是一种新发现的一类依赖Zn2+分泌型金属蛋白酶。Adamts5目前在骨关节炎、心血管疾病、肿瘤等多种疾病中有着密切的关系。随着人类对Adamts5的逐步了解，推测Adamts5这个功能复杂的金属蛋白酶未来可在医学领域的疾病研究、药物治疗方面发挥强大的作用，论文将对其相关内容进行综述。

关键词

Adamts5；癌症；冠状动脉粥样硬化心脏病；肥胖；骨关节炎

参考

王利,王宪,孔炜.新型金属蛋白酶ADAMTS家族的研究进展[J].生理科学进展,2008(1):49-52.

陈小云.ADAMTS4和ADAMTS5基因多态性与冠心病相关性研究[D].重庆:重庆医科大学,2018.

A J Fosang, F M Rogerson, C J East, et al. ADAMTS-5: The story so far[J]. European Cells and Materials (ECM),2008(15):1.

Li Kui Wang, Zhi-Wei Hu, Zhipeng Ren, et al. Assessing Serum Levels of ADAMTS1 and ADAMTS4 as New Biomarkers for Patients with Type A Acute Aortic Dissection[J]. Medical science monitor: international medical journal of experimental and clinical research,2017(23):7.

Lynch M, Barallobre-Barreiro J, Jahangiri M, et al. Vascular proteomics in metabolic and cardiovascular diseases[J]. Intern Med,2016,280(4):325-338.

Wu Wenjing, Zhou Yifeng, Li Yiyang, et al. Association between plasma ADAMTS-7 levels and ventricular remodeling in patients with acute myocardial infarction[J]. European journal of medical research,2015(20):1-5.

Cheol Whan Lee, Ilseon Hwang, Chan-Sik Park, et al. Comparison of ADAMTS-1, -4 and -5 expression in culprit plaques between acute myocardial infarction and stable angina[J]. Journal of Clinical Pathology,2011,64(5):9.

Ozkaramanli Gur D, Guzel S, Akyuz A, et al. The role of novel cytokines in inflammation: Defining peripheral artery disease among patients with coronary artery disease[J]. Vasc Med,2018,23(5):

-436.

Zhen Wang, Di Ye, Jing Ye, et al. ADAMTS-5 Decreases in Coronary Arteries and Plasma from Patients with Coronary Artery Disease[J]. Disease Markers,2019(2019):6129748.

Suna G, Wojakowski W, Lynch M, et al. Extracellular Matrix Proteomics Reveals Interplay of Aggrecan and Aggrecanases in Vascular Remodeling of Stented Coronary Arteries[J]. Circulation,2018,137(2):166-183.

Varun K Krishnamurthy, Amy M Opoka, Christine B Kern, et al. Maladaptive matrix remodeling and regional biomechanical dysfunction in a mouse model of aortic valve disease[J]. Matrix Biology,2012,31(3):790.

Edwin C M Mariman, Ping Wang. Adipocyte extracellular matrix composition, dynamics and role in obesity[J]. Cellular and Molecular Life Sciences,2010,67(8):8.

Gabor Voros, John D Sandy, Désiré Collen, et al. Expression

of aggrecan(ases) during murine preadipocyte differentiation and adipose tissue development[J]. BBA-General Subjects, 2006,1760(12):76579.

Voros Gabor, Maquoi Erik, Collen Désiré, et al. Differential expression of plasminogen activator inhibitor-1, tumor necrosis factor-alpha, TNF-alpha converting enzyme and ADAMTS family members in murine fat territories.[J]. Biochimica et biophysica acta,2003,1625(1):3795-3799.

Dries Bauters, Mathias Cobbaut, Lotte Geys, et al. Loss of ADAMTS5 enhances brown adipose tissue mass and promotes browning of white adipose tissue via CREB signaling[J]. Molecular Metabolism,2017,6(7):9.

Aydos SE, Yukselten Y, Sunguroglu A, et al. Role of ADAMTS1 and ADAMTS5 in male infertility[J]. Andrologia, 2016,48(10):1113-1119.

Li C, Xiong Y, Yang X, et al. Lost expression of ADAMTS5 protein associates with progression and poor prognosis of hepatocellular carcinoma[J]. Drug Des Devel Ther, 2015,24(9):1773-1783.

Filou S, Stylianou M, Triantaphyllidou IE, et al. Expression and distribution of aggrecanases in human larynx: ADAMTS-5/aggrecanase-2 is the main aggrecanase in laryngeal carcinoma[J]. Biochimie,2013,95(4):725-734.

顾俊.ADAMTS5与非小细胞肺癌的相关性研究[D].苏州:苏州大学,2016.

Haraguchi Naotsugu, Ohara Nobuyoshi, Koseki Jun, et al. High expression of ADAMTS5 is a potent marker for lymphatic invasion and lymph node metastasis in colorectal cancer[J]. Molecular and clinical oncology,2017,6(1):78-96.

Zhu Z, Xu J, Wu X, et al. In Silico Identification of Contradictory Role of ADAMTS5 in Hepatocellular Carcinoma[J]. Technol Cancer Res Treat, 2021(20):1533033820986826.

Troeberg L, Nagase H. Proteases involved in cartilage matrix degradation in osteoarthritis[J]. Biochim Biophys Acta, 2012,1824(1):133-145.

Dimitrije Krstic, Myriam Rodriguez, Irene Knuesel. Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators[J]. PLoS ONE,2017,7(10):67-73.

Fushimi K, Troeberg L, Nakamura H, et al. Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity[J]. Biol Chem,2008,283(11):6706-6716.

Glasson SS, Askew R, Sheppard B, et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis[J]. Nature, 2005,434(7033):644-648.

Siebuhr AS, Werkmann D, Bay-Jensen AC, et al. The Anti-ADAMTS-5 Nanobody®M6495 Protects Cartilage Degradation Ex Vivo[J]. Int J Mol Sci,2020,21(17):5992.

Tajima T, Sekimoto T, Yamaguchi N, et al. Hemoglobin stimulates the expression of ADAMTS-5 and ADAMTS-9 by synovial cells: a possible cause of articular cartilage damage after intra-articular hemorrhage[J]. BMC Musculoskelet Disord,2017,18(1):449.

Apte SS. Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis[J]. Biochem,2016,473(1):1-4.

Santamaria S, Yamamoto K, Botkjaer K, et al. Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)[J]. Biochem,2015,471(3):391-401.

Song XY, Xie WP, Zhang P, et al. Cangxitongbi capsule protects articular cartilage of the knee in rats by regulating ADAMTS-5[J]. Ann Transl Med,2020,8(22):1511.

Zhang Y, Wang G, Ma L, et al. miR-137 suppresses cell growth and extracellular matrixdegradation through regulating ADAMTS-5 in chondrocytes[J]. Am J Transl Res,2019,11(11):7027-7034.

DOI: http://dx.doi.org/10.12345/yzlcyxzz.v5i2.11286