慢性阻塞性肺疾病氧化应激机制研究进展

艳艳 刘(内蒙古医科大学，中国;内蒙古自治区人民医院 国家卫健委慢阻肺诊治重点实验室，内蒙古自治区呼吸疾病重点实验室，中国)
德俊 孙(内蒙古自治区人民医院 国家卫健委慢阻肺诊治重点实验室，内蒙古自治区呼吸疾病重点实验室，中国)

摘要

慢性阻塞性肺疾病（COPD）是一种严重危害人类健康的慢性呼吸系统疾病，其发病机制是目前的研究热点，主要包括炎症机制、氧化应激机制、蛋白酶/抗蛋白酶失衡机制及免疫失衡机制等。其中，氧化应激机制是COPD发生及发展的主要驱动机制，它不仅可以直接引起气道及肺组织的氧化损伤，还可以激活COPD的其他机制引发一系列病理生理的损害。因此，抗氧化剂在COPD的治疗中受到较多关注，并积累了较为丰富的循证证据和临床应用经验。论文通过介绍COPD中氧化应激机制及抗氧化治疗，为COPD的研究及治疗提供新的方向，以降低COPD所带来的社会经济负担。

关键词

慢性阻塞性肺疾病；氧化应激；氧化剂；抗氧化剂

参考

陈亚红.2022年GOLD慢性阻塞性肺疾病诊断、治疗、管理及预防全球策略更新要点解读[J/OL].中国全科医学:1-12[2022-03-03].

Wang C, Xu J Y, Yang L, et al. Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study[J].Lancet,2018,391(10131):1706-1717.

Birben E, Sahiner UM, Sackesen C, et al. Oxidative stress and antioxidant defense[J]. World Allergy Organ J, 2012, 5(1):9-19.

Taniguchi A, Tsuge M, Miyahara N, et al. Reactive Oxygen Species and Antioxidative Defense in Chronic Obstructive Pulmonary Disease[J]. Antioxidants (Basel), 2021, 10(10):1537.

Barnes P J. Oxidative stress-based therapeutics in COPD[J].Redox Biology, 2020,33(7):101544.

Annesley SJ, Fisher PR. Mitochondria in Health and Disease[J].Cells,2019(7):680.

Boukhenouna S, Wilson MA, Bahmed K, et al. Reactive Oxygen Species in Chronic Obstructive Pulmonary Disease[J].Oxid Med Cell Longev,2018(11):5730395.

Zinellu E, Zinellu A, Pau MC, et al. Glutathione Peroxidase in Stable Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis[J].Antioxidants (Basel),2021(11):1745.

Zuo L, He F, Sergakis GG, et al. Interrelated role of cigarette smoking, oxidative stress, and immune response in COPD and corresponding treatments[J].Physiol Lung Cell Mol Physiol, 2014(3):205-218.

Taggart C, Cervantes-Laurean D, Kim G, et al. Oxidation of either methionine 351 or methionine 358 in alpha 1-antitrypsin causes loss of anti-neutrophil elastase activity[J].Biol Chem,2000(35):27258-27265.

Reynaert NL. Time to Shift Focus from Oxidative Stress to Redox Regulation in COPD[J].Antioxidants (Basel),2022(2):237.

Jiang Y, Wang X, Hu D. Mitochondrial alterations during oxidative stress in chronic obstructive pulmonary disease[J].Chron Obstruct Pulmon Dis,2017(12):1153-1162.

Dalle-Donne I, Rossi R, Colombo R, et al. Biomarkers of oxidative damage in human disease[J].Clin Chem,2006(4):601-623.

Zheng JP, Wen FQ, Bai CX, et al. PANTHEON study group. Twice daily N-acetylcysteine 600 mg for exacerbations of chronic obstructive pulmonary disease (PANTHEON): a randomised, double-blind placebo-controlled trial[J].Lancet Respir Med,2014(3):187-194.

Papi A, Zheng J, Criner GJ, et al. Impact of smoking status and concomitant medications on the effect of high-dose N-acetylcysteine on chronic obstructive pulmonary disease exacerbations: A post-hoc analysis of the PANTHEON study[J].Respir Med,2019(9):37-43.

Aldini G, Altomare A, Baron G, et al. N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why[J].Free Radic Res,2018(7):751-762.

Biswas S, Hwang JW, Kirkham PA, et al. Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease[J].Curr Med Chem,2013(12):1496-1530.

徐海燕,贾维.Nrf2在中医药治疗慢性阻塞性肺疾病作用机制中的研究进展[J].湖北中医药大学学报,2021,23(5):122-125.

Yang YC, Lii CK, Lin AH, et al. Induction of glutathione synthesis and heme oxygenase 1 by the flavonoids butein and phloretin is mediated through the ERK/Nrf2 pathway and protects against oxidative stress[J].Free Radic Biol Med,2011(11):2073-2081.

Gutierrez-Mariscal FM, Arenas-de Larriva AP, Limia-Perez L, et al. Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases[J].Mol Sci,2020(21):7870.

Kang L, Liu S, Li J, et al. The mitochondria-targeted anti-oxidant MitoQ protects against intervertebral disc degeneration by ameliorating mitochondrial dysfunction and redox imbalance[J].Cell Prolif,2020(3):12779.

Wiegman CH, Michaeloudes C, Haji G, et al. COPDMAP. Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease[J].Allergy Clin Immunol,2015(3):769-780.

Hara H, Araya J, Ito S, et al. Mitochondrial fragmentation in cigarette smoke-induced bronchial epithelial cell senescence[J].Physiol Lung Cell Mol Physiol,2013(10):737-746.

DOI: http://dx.doi.org/10.12345/yzlcyxzz.v5i3.11516