血管内皮生长因子与糖肾足细胞的研究进展

海月 戚(内蒙古医科大学，中国)
冬梅 李(内蒙古自治区人民医院内分泌科，中国)
其木格 娜仁(内蒙古自治区人民医院内分泌科，中国)

摘要

糖尿病肾病（Diabetic Nephropathy，DN）是糖尿病最常见和最严重的微血管并发症之一，早期临床症状不明显，随着病情的进展及糖尿病病程的延长，逐渐出现蛋白尿、水肿、高血压等一系列临床表现，最终进展为终末期肾脏病，这也是糖尿病患者的主要死因之一，因此糖尿病肾病的发病机制亟待明确。目前关于糖尿病肾病的发病机制的研究主要包括肾脏血流动力学改变、糖代谢紊乱、脂代谢紊乱、表观遗传学机制、氧化应激、各种细胞因子及自噬等，以上因素可通过不同的机制及相互作用导致足细胞损伤，最终导致DN的发生发展，其中血管内皮生长因子（Vascular Endothelial Growth Factor，VEGF）直接参与足细胞损伤的过程。论文主要就血管内皮生长因子与足细胞损伤的关系进行探讨，旨在为延缓DN进展、改善患者生活质量提供临床治疗思路。

关键词

血管内皮生长因子；糖尿病肾病；足细胞损伤

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v5i6.11897