MODY3的致病机制研究现状

兆敏 李(内蒙古医科大学研究生学院，中国)
冬梅 李(内蒙古自治区人民医院内分泌科，中国)
园园 李(内蒙古自治区人民医院内分泌科，中国)

摘要

青少年起病的成人型糖尿病（MODY）是一种常染色体显性遗传的单基因糖尿病。目前已发现的MODY致病基因至少有14种，其中MODY3型是由编码转录因子-肝细胞核因子1α（HNF-1α）的基因突变引起的。MODY3常在儿童期、青春期或成年早期发病，具有进行性高血糖特征和慢性糖尿病微血管并发症的高风险。论文主要围绕MODY3的致病机制研究现状作一综述。

关键词

MODY3；HNF-1α；致病机制

参考

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v5i7.11902