结肠息肉和结直肠癌中 Hippo 通路的表达变化及转化机制研究

彤 邱(内蒙古自治区人民医院，中国)
佳林 王(内蒙古自治区人民医院消化内科，中国)

摘要

在中国，结直肠癌的发病率位居第三，Hippo通路作为一条维持组织稳态、控制器官大小的抑癌信号转导通路，参与结直肠癌的发生发展过程，Merlin是目前已知的Hippo通路上游唯一一个肿瘤抑制基因。遵循腺瘤-癌机制，腺瘤性息肉经历异型增生阶段转变为浸润性癌症，因此，研究Merlin和Hippo通路在结肠息肉、结直肠癌以及二者转化过程中的表达变化，可以为早期结直肠癌的诊断提供理论依据，同时为结直肠癌的靶向治疗提供新的思路。

关键词

Hippo信号通路；Merlin；结肠息肉；结直肠癌

参考

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v6i1.12311