高血压合并肥胖患者脂肪组织对血压的影响及治疗

宇 贾(内蒙古医科大学，中国)
兴胜 赵(内蒙古医科大学，中国)

摘要

高血压是世界范围内导致过早死亡的主要原因，是一种严重疾患，会显著加剧罹患心脏、大脑、肾脏疾病以及其他疾病的风险。然而，我们已知高血压与肥胖密切相关，肥胖会增加高血压的患病风险；世界卫生组织（World Health Organization，WHO）统计，全世界估计有12.8亿30~79岁成年人患有高血压，中国高血压患病人群达2.45亿，这是一个重大的健康和经济负担。肥胖相关性高血压可能涉及的机制包括交感神经系统激活、肾素-血管紧张素-醛固酮系统激活、大脑神经机制、肾脏损伤、血管改变、脂肪组织病变、免疫和炎症机制等，本综述重点探讨脂肪组织衍生分泌因子在肥胖期间对血压的影响，旨在通过改善脂肪组织功能、减少脂肪组织来更好地控制血压。

关键词

高血压；肥胖；脂肪组织；心血管疾病

参考

Heinonen S, Jokinen R, Rissanen A, et al. White adipose tissue mitochondrial metabolism in health and in obesity[J]. Obes Rev, 2020(2).

Horrillo R, Gonzalez-Periz A, Martinez-Clemente M, et al. 5-Lipoxygenase Activating Protein Signals Adipose Tissue Inflammation and Lipid Dysfunction in Experimental Obesity[J]. Journal of Immunology, 2010,184(7):3978-3987.

Ca H D. Metabolic Control by Inflammation and Immunity: Obesity-associated extracellular mtDNA activates central TGFbeta pathway to cause blood pressure increase[J]. American Journal of Physiology, 2017,312(3aPta1).

Demarco V G, Aroor A R, Sowers J R. The pathophysiology of hypertension in patients with obesity[J]. Nature Reviews Endocrinology, 2014,10(6):364-376.

Tsou M T, Yun C H, Lin J L , et al. Visceral Adiposity, Pro-Inflammatory Signaling and Vasculopathy in Metabolically Unhealthy Non-Obesity Phenotype[J]. Diagnostics, 2020,11(1):40.

Lee D Y, Lee M Y, Sung K C. Prediction of Mortality with A Body Shape Index in Young Asians: Comparison with Body Mass Index and Waist Circumference[J]. Obesity, 2018,26(6).

Bahler L, Verberne H J, Admiraal W M, et al. Differences in Sympathetic Nervous Stimulation of Brown Adipose tissue between the young and old and the lean and obese.[J]. The Journal of Nuclear Medicine, 2016(3).

Virtanen K A, Lidell M E, Orava J, et al. Brief Report: Functional Brown Adipose Tissue in Healthy Adults[J]. New England Journal of Medicine, 2009,360(15):1518-1525.

Lidell M E, Betz M J, Leinhard O D, et al. Evidence for two types of brown adipose tissue in humans[J/OL]. Nature Medicine, 2013,19(5):631-634.

Wu J, Bostrm P, Sparks L, et al. Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human[J]. Cell, 2012, 150(2):366-376.

Y-J Gao, Lu C , L-Y Su, et al. Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide[J]. British Journal of Pharmacology, 2010,151(3).

B Ga´lvez-Prieto, Bolbrinker J, Stucchi P, et al. Comparative expression analysis of the renin-angiotensin system components between white and brown perivascular adipose tissue[J]. Journal of Endocrinology, 2008,197(1):55.

Rahmouni K, Mark A L, Haynes W G, et al. Adipose depot-specific modulation of angiotensinogen gene expression in diet-induced obesity[J]. American Journal of Physiology Endocrinology & Metabolism, 2004,286(6):E891.

DOI: http://dx.doi.org/10.12345/yzlcyxzz.v6i4.12535