粪便钙卫蛋白在婴幼儿牛奶蛋白过敏中的应用现状

健 张(内蒙古医科大学研究生院，中国)
瑞凤 李(内蒙古妇幼保健院儿内科，中国)

摘要

牛奶蛋白过敏是指机体对一种或几种牛奶蛋白产生的可重复出现的由免疫机制介导的机体不良反应，多见于婴幼儿时期，目前获得耐受的相关机制仍不清楚，其症状多无特异性，表现轻重不一，主要累及皮肤、消化系统和呼吸道系统等，导致早期诊断困难。临床上婴幼儿腹泻如果治疗不及时，极易导致腹泻迁延不愈，甚至出现血便、腹胀、反复呕吐等症状，严重者可影响儿童生长发育。由于本病容易出现漏诊、误诊、诊断延迟等，加上诊断及动态监测病情目前无特异性生物学指标，故寻找特异性生物学指标对帮助早期诊断非常重要。论文就粪便钙蛋白在婴幼儿牛奶蛋白过敏症中的应用现状作一综述。

关键词

婴幼儿；牛奶蛋白过敏；粪便钙卫蛋白；生物标志物

参考

Flom J D,Sicherer S H. Epidemiology of Cow’s Milk Allergy[J].

Nutrients,2019,11(5):1051.

Mousan G,Kamat D. Cow’s Milk Protein Allergy[J]. Clin Pediatr

(Phila),2016,55(11):1054-1063.

Yang M, Tan M, Wu J, et al. Prevalence, Characteristics, and

Outcome of Cow’s Milk Protein Allergy in Chinese Infants:

A Population-Based Survey[J]. JPEN J Parenter Enteral

Nutr,2019,43(6):803-808.

葛静静,刘秀梅,矫晓玲,et al.婴儿早期不同程度过敏风险高危因

素大样本调查[J].中国微生态学杂志,2019,31(7):820-824.

Lopes J P, Sicherer S. Food allergy: epidemiology, pathogenesis,

diagnosis, prevention, and treatment[J]. Curr Opin Immunol,

(66):57-64.

Giannetti A, Toschi Vespasiani G, Ricci G, et al. Cow’s Milk

Protein Allergy as a Model of Food Allergies[J]. Nutrients,

,13(5):1525.

Calvani M, Anania C, Cuomo B, et al. Non-IgE- or Mixed IgE/

Non-IgE-Mediated Gastrointestinal Food Allergies in the First

Years of Life: Old and New Tools for Diagnosis[J]. Nutrients,

,13(1):226.

Schäfer B W, Heizmann C W. The S100 family of EF-hand

calcium-binding proteins: functions and pathology[J]. Trends

Biochem Sci, 1996,21(4):134-140.

Brun J G, Ulvestad E, Fagerhol M K, et al. Effects of human

calprotectin (L1) on in vitro immunoglobulin synthesis[J]. Scand J

Immunol,1994,40(6):675-680.

Murao S, Collart F R,Huberman E. A protein containing the

cystic fibrosis antigen is an inhibitor of protein kinases[J]. J Biol

Chem,1989,264(14):8356-8360.

Yui S, Nakatani Y,Mikami M. Calprotectin (S100A8/S100A9),

an inflammatory protein complex from neutrophils with a broad

apoptosis-inducing activity[J]. Biol Pharm Bull,2003,26(6):

-760.

曾俊祥,吕婕,罗婷, et al.粪便钙卫蛋白不同检测方法分析前及分

析中影响因素分析[J].临床检验杂志,2020,38(6):422-426.

Peura S, Fall T, Almqvist C, et al. Normal values for calprotectin

in stool samples of infants from the population-based

longitudinal born into life study[J]. Scand J Clin Lab Invest,

,78(1-2):120-124.

Caffarelli C, Baldi F, Bendandi B, et al. Cow’s milk protein allergy

in children: a practical guide[J]. Ital J Pediatr,2010(36):5.

Koletzko S, Niggemann B, Arato A, et al. Diagnostic approach and

management of cow’s-milk protein allergy in infants and children:

ESPGHAN GI Committee practical guidelines[J]. J Pediatr

Gastroenterol Nutr,2012,55(2):221-229.

DOI: http://dx.doi.org/10.12345/yzlcyxzz.v6i12.14893