NR4A1、NR4A2、IL-36 与冠状动脉性心脏病及心肌缺血再灌注损伤关系的研究进展

文 李(承德医学院附属医院，中国)
振江 丁(承德医学院附属医院，中国)

摘要

核受体亚家族4A组成员1（ Nuclear receptor subfamily 4group Amember 1， NR4A1）及核受体亚家族4A组成员2（ Nuclearreceptor subfamily 4group Amember 2， NR4A2）是核受体亚家族4A组中的成员，是经典的炎症调控因子，同时参与脂质代谢的调节及心肌细胞缺血再灌注(Myocardial ischemia-reperfusion injury， MIRI)。近期研究提示白介素36（ IL-36）与冠状动脉性心脏病（ Coronary heart disease， CHD）的诊断、评估病变的严重程度及MIRI等方面有相关性。论文通过对NR4A1、NR4A2、 IL-36与CHD、 MIRI的相关性进行概述，期望为CHD的早期诊断、治疗及改善预后提供新方向。

关键词

核受体亚家族4A组成员1；核受体亚家族4A组成员2；白介素-36；冠状动脉性心脏；心肌细胞缺血再灌注

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v6i12.14898