IL-18、UCH-L1 与慢性低灌注在脑白质高信号机制中的研究进展

雪 姚(承德医学院附属医院，中国)
晓璇 张(承德医学院附属医院，中国)
瑶 刘(承德医学院附属医院，中国)

摘要

白介素-18（ IL-18）是一种促炎细胞因子，泛素羧基末端水解酶L1（ UCH-L1）是一种在大脑中含量占比较高的蛋白质，脑白质高信号目前是脑小血管病的主要影像学表现，通过对脑白质高信号机制的研究，可能降低人群患病率，而这两种因子均可能与脑白质高信号（ WMH）的发病机制有相关性，可能在血脑屏障受损、炎症反应等机制均有关联。论文通过对IL-18、 UCH-L1与WMH的相关性进行概述，期望对WMH的诊断、治疗及改善预后率提供方法，而脑缺血低灌注也有可能导致脑白质高信号，论文也将研究两者关系从而进一步研究。

关键词

白介素-18；泛素羧基末端水解酶L1；慢性低灌注；脑白质高信号

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v6i12.14907