PHLPP2对肿瘤表达的研究进展

耀伟 王(承德医学院附属医院，中国)
春丽 刘(承德医学院附属医院，中国)

摘要

肿瘤严重威胁着人类的生命健康，因此探索高效的肿瘤早期诊断、治疗和预后方法一直是医学领域的研究重点。近年来，有大量研究发现PHLPP2在肿瘤治疗方面展示出了巨大潜力。PHLPP2是一种丝氨酸/苏氨酸磷酸酶，亚历山德拉·牛顿（Alexandra Newton）博士首次发现PHLPP是一种有效的肿瘤抑制因子，目前研究中，已经证实PHLPP2可以通过AGC激酶家族、蛋白激酶C（PKC）、核糖体蛋白S6激酶（S6K）和巨噬细胞刺激蛋白1（Mst1）这些底物的去磷酸化抑制细胞生长和存活，并促进肿瘤抑制。论文将对PHLPP2的功能、信号通路以及其在各类肿瘤中表达的研究进展进行综述，旨在为肿瘤治疗提供新的靶点。

关键词

PHLPP2；肿瘤；进展

参考

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i1.15610