细胞骨架蛋白变异在心房颤动中的研究进展

明洋 袁(承德医学院附属医院，中国)
舒承 李(承德医学院附属医院，中国)

摘要

心房颤动（Atrial fibrillation ，AF）是临床上最常见的快速性心律失常，该病可继发于其他疾病，如高血压、心脏瓣膜病和心力衰竭，从而增加脑梗死和猝死的风险。最近人们认识到，在房颤人群中15%的人是家族性的。各项流行病学的研究的证据表明，遗传因素在房颤的发病中起着重要作用。迄今为止，在离子通道、细胞骨架蛋白、炎症、钙处理蛋白相关的一系列基因中已经发现几种罕见的变异。然而，心房颤动的遗传学是相当复杂的，其中的病理生理学机制仍未解开。在这里我们集中论述遗传性房颤相关的细胞骨架蛋白基因变异，以及驱动这种心律失常的潜在病理生理途径。

关键词

心房颤动；家族性；基因；细胞骨架蛋白；遗传

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i1.15612