开放期刊系统

MME、MECOM及其在2型糖尿病性骨质疏松中的研究进展

一凡 张(承德医学院附属医院,中国)
晓燕 刘(承德医学院附属医院,中国)
昊 许(承德医学院附属医院,中国)

摘要

随着人口老龄化的进展,糖尿病越来越受到人们的重视,而骨质疏松作为糖尿病的慢性并发症之一,其发病率逐年上升。2型糖尿病性骨质疏松的发生发展涉及糖代谢、骨代谢等多种机制,发病机制复杂,而目前的研究尚不明确,系统性地了解2型糖尿病性骨质疏松的发病机制,可为糖尿病合并骨质疏松患者的临床治疗提供更多思路,从而降低糖尿病患者不良事件的风险。论文将从MME、MECOM在2型糖尿病性骨质疏松中的研究进展及2型糖尿病性骨质疏松的发病机制进行阐述,进一步明确骨质疏松与2型糖尿病的关系。

关键词

2型糖尿病;骨质疏松;膜金属内肽酶;MDS1和EVI1复合位点

全文:

PDF

参考

Sun H, Saeedi P, Karuranga S, et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045 [J]. Diabetes Res Clin Pract,2022(183):109119.

应大文,刘芳.糖尿病与骨质疏松的相关性研究进展[J].实用预防医学,2015,22:1275-1278.

夏维波.应重视糖尿病性骨质疏松症[J].中华糖尿病杂志,2016

(8):1-4.

Skidgel RA, Engelbrecht S, Johnson AR, et al. Hydrolysis of substance p and neurotensin by converting enzyme and neutral endopeptidase. Peptides[J]. 1984,5(4):769-76.

Gafford JT, Skidgel RA, Erdös EG, et al. Human kidney “enkephalinase”, a neutral metalloendopeptidase that cleaves active peptides. Biochemistry[J]. 1983,22(13):3265-3271.

Brandt I, Lambeir AM, Ketelslegers JM, et al. Dipeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-SerPro form [J]. Clin Chem, 2006,52(1):82-87.

Malek V, Sharma N, Gaikwad AB. Histone Acetylation Regulates Natriuretic Peptides and Neprilysin Gene Expressions in Diabetic Cardiomyopathy and Nephropathy [J].Curr Mol Pharmacol,2019,12(1):61-71.

Willard JR, Barrow BM, Zraika S, et al. Improved glycaemia in high-fat-fed neprilysin-deficient mice is associated with reduced DPP-4 activity and increased active GLP-1 levels [J]. Diabetologia,2017,60(4):701-708.

Ruchon AF, Marcinkiewicz M, Ellefsen K, et al. Cellular localization of neprilysin in mouse bone tissue and putative role in hydrolysis of osteogenic peptides[J]. Bone Miner Res,2000,15(7):1266-1274.

Granéli C, Thorfve A, Ruetschi U, et al. Novel markers of osteogenic and adipogenic differentiation of human bone marrow stromal cells identified using a quantitative proteomics approach [J].Stem Cell Res,2014,12(1):153-165.

Montagna G, Pani G, Flinkman D, et al. Long-term osteogenic differentiation of human bone marrow stromal cells in simulated microgravity: novel proteins sighted [J]. Cell Mol Life Sci,2022,79(10):536.

Miller RA, Kutmon M, Bohler A, et al. Understanding signaling and metabolic paths using semantified and harmonized information about biological interactions [J]. PLoS One,2022,17(4):e0263057.

Lazarenko V, Churilin M, Azarova I, et al. Comprehensive Statistical and Bioinformatics Analysis in the Deciphering of Putative Mechanisms by Which Lipid-Associated GWAS Loci Contribute to Coronary Artery Disease [J]. Biomedicines. 2022,10(2):259.

Naito T, Yokoyama N, Kakuta Y, et al. Clinical and genetic risk factors for decreased bone mineral density in Japanese patients with inflammatory bowel disease [J].J Gastroenterol Hepatol,2018,33(11):1873-1881.

Hwang JY, Lee SH, Go MJ, et al. Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture [J].J Med Genet,2013,50(4):212-219.

Alliston T, Ko T, Cao Y, et al. Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1[J].J Biol Chem,

(280):24227-24237.

Nitta E, Izutsu K, Yamaguchi Y, et al. Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP[J]. Oncogene,2005(24):6165-6173.

Juneja SC, Vonica A, Zeiss C, et al. Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia[J]. Bone,2014(60):148-161.

李敏启,杜娟,杨盼盼,等.氧化应激调控骨质疏松症的研究进展[J].山东大学学报(医学版),2021,59(6):16-24.

Botolin S, McCabe LR. Inhibition of PPARgamma prevents type I diabetic bone marrow adiposity but not bone loss[J]. J Cell Physiol, 2006,209(3):967-976.

ALHARBI M A, ZHANG C, LU C, et al. FOXO1 deletion reverses the effect of diabetic-induced impaired fracture healing[J]. Diabetes,2018,67(12):2682-2694.

Kyong-Chol Kim, Dong-Hyuk Shin, Set-Young Lee, et a1. Relation between obesity and bone mineral density and vertebral fractures in korean postmenopausal women [J]. Yonsei Med,2010,51(6):857-863.

Gunaratnam K, Vidal C, Gimble JM, et al. Mechanisms of palmitateinduced lipotoxicity in human osteoblasts[J]. Endocrinology,2014,155(1):108-116.

张宝伟,雷涛.肥胖与骨质疏松[J].国际内分泌代谢杂志,2010,30

(4):242-244.

SUZUKI R, FUJIWARA Y, SAITO M, et al. Intracellular accumulation of advanced glycation end products induces osteoblast apoptosis via endoplasmic reticulum stress[J]. Journal of Bone and Mineral Research,2020,35(10):1992- 2003.

付文萍.晚期糖基化终末产物与2型糖尿病患者骨代谢及骨密度的相关性研究[J].中国全科医学,2013,16(2):154-157.

Pramojanee SN, Phimphilai M, Kumphune S, et al. Decreased jaw bone density and osteoblastic insulin signaling in a model of obesity[J]. J Dent Res,2013,92(6):560-565.

Huang CQ, Ma GZ, Tao MD, et al. The relationship among renal injury, changed activity of renal 1-alpha hydroxylase and bone loss in elderly rats with insulin resistance or type 2 diabetes mellitus[J]. J Endocrinol Invest,2009,32(3):196-201.

邱红丽.全面优质护理对老年糖尿病合并高血压患者治疗依从性及其对疾病认知度的影响分析[J].实用糖尿病杂志,2018,

(3):56-57.

LI X, ZHOU Z Y, ZHANG Y Y, et al. IL-6 contributes to the defective osteogenesis of bone marrow stromal cells from the vertebral body of the glucocorticoid-induced osteoporotic mouse[J]. PLoS One,2016,11(4):e0154677.

Strand M, Soderstrom I, Wiklund PG, et al.Polymorphisms at the osteoprotegerin and interleukin-6 genes in relation to first-ever stroke [J]. Cerebrovasc Dis, 2007,24(5):418-25.

常志芳,冯成龙,史晓霞,等.免疫与骨质疏松的研究进展[J].中国骨质疏松杂志,2015,21(4):508-513.

Alonso-Magdalena P, Quesada I, Nadal A. Endocrine disruptors in the etiology of type 2 diabetes mellitus[J]. Nat Rev Endocrinol, 2011,7(6):346-353.

Tiano JP, Mauvais-Jarvis F. Molecular mechanisms of estrogen receptors’ suppression of lipogenesis in pancreatic beta-cells[J]. Endocrinology,2012,153(7):2997-3005.

Chen JF, Lin PW, Tsai YR, et al. Androgens and androgen receptor actions on bone health and disease: from androgen deficiency to androgen therapy[J]. Cells,2019,8(11):1318.



DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i3.16235

Refbacks

  • 当前没有refback。
版权所有(c)2024 一凡 张, 晓燕 刘, 昊 许 Creative Commons License
此作品已接受知识共享署名-非商业性使用 4.0国际许可协议的许可。
  • :+65-62233778 QQ:2249355960 :contact@s-p.sg