轻度认知功能障碍体液生物标志物的研究进展

翔宇 郭(承德医学院附属医院，中国)
翠 赵(承德医学院附属医院，中国)

摘要

轻度认知功能障碍（mild cognitive impairment，MCI）是指视空间执行能力、定向力或其他认知功能减退，但基本生活能力没有受到影响，尚不能够诊断为痴呆，它是介于正常衰老和痴呆的一种中间状态。据统计，每年从MCI发展为阿尔茨海默病（Alzheimer’s disease，AD）的比例为10%~15%，且目前缺乏有效的药物治疗痴呆，给社会和家庭造成了严重的影响。MCI的早期发现，可在阻止这一过程的进展基础上，阻止痴呆的发生，因此在MCI阶段积极寻找特异性血液标记物成为目前研究的主要话题。论文主要从目前MCI常见的体液标记物进行介绍。

关键词

轻度认知功能障碍；阿尔茨海默病；体液标记物；痴呆

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i3.16249