新生儿惊厥临床研究进展分析

梦晓 严(承德医学院附属医院，中国)
彦秋 武(承德医学院附属医院，中国)

摘要

新生儿惊厥是新生儿出生后早期最常见的神经系统急症之一。新生儿惊厥最常见的病因为新生儿缺氧缺血性脑病，近年来随着围产医学及新生儿重症监护诊疗技术的发展，临床中新生儿缺氧缺血性脑病的发病率逐渐下降，随着现代医学的发展，振幅整合脑电图及基因检测技术的应用，一些不易察觉的病因的发病率逐渐增加。尽早地明确病因对于后期的指导治疗、降低脑损伤的风险，减少癫痫和神经功能损伤具有重要意义。本次综述主要是就国内外近几年关于新生儿惊厥发病的病因、临床表现、诊断依据及治疗做个初步的总结。

关键词

新生儿惊厥；病因；临床特点；诊断；治疗

参考

Acar DB, Bulbul A, Uslu S. Current Overview of Neonatal Convulsions[J]. Sisli Etfal Hastan Tip Bul,2019,53(1):1-6.

Poston JM, Rebholz A. Neonatal Seizures: Core Concepts[J]. Neonatal Netw,2021,40(6):362-368.

Gunawardane N, Fields M. Acute Symptomatic Seizures and Provoked Seizures: to Treat or Not to Treat?[J]. Curr Treat Options Neurol,2018,20(10):41.

Beghi E, Carpio A, Forsgren L, Hesdorffer DC, Malmgren K, Sander JW, et al.Recommendation for a definition of acute symptomatic seizure[J]. Epilepsia,2010(51):671-675.

Kadish NE, Bast T, Reuner G, et al. Epilepsy surgery in the first 3 years of life: predictors of seizure freedom and cognitive development[J]. Neurosurgery, 2019,84:E368-377.

Pressler RM, Cilio MR, Mizrahi EM, et al. The ILAE classification of seizures and the epilepsies: Modification for seizures in the neonate[J]. Position paper by the ILAE Task Force on Neonatal Seizures Epilepsia,2021,62(3):615-628.

Vasudevan C, Levene M. Epidemiology and aetiology of neonatal seizures[J]. Semin Fetal Neonatal Med, 2013(18):185-191.

Cornet MC, Sands TT, Cilio MR. Neonatal epilepsies: clinical management[J]. Semin Fetal Neonatal Med, 2018,23(3):204-212.

Scheffer IE, Berkovic S, Capovilla G, et al. ILAE classification of the epilepsies: position paper of the ILAE commission for classification and terminology[J]. Epilepsia, 2017(58):512-521.

Beal JC, Cherian K, Moshe SL. Early-onset epileptic encephalopathies: ohtahara syndrome and early myoclonic encephalopathy[J]. Pediatr Neurol, 2012(47):317-323.

Axeen EJT, Olson HE. Neonatal epilepsy genetics[J]. Semin Fetal Neonatal Med, 2018,23(3):197-203.

Pisano T, Numis AL, Heavin SB, et al. Early and effective treatment of KCNQ2 encephalopathy[J]. Epilepsia, 2015(56):685-691.

李露莹,陈锦.新生儿癫痫病因、临床表现及脑电图特点概述[J].癫痫杂志,2023,9(2):156-159.

Nguyen T, Wusthoff CJ. Clinical manifestations of neonatal seizures[J]. Pediatr Int, 2021,63(6):631-635.

Ziobro J, Shellhaas RA. Neonatal Seizures: Diagnosis, Etiologies, and Management[J]. Semin Neurol, 2020,40(2):246-256.

Shellhaas RA. Continuous long-term electroencephalography: the gold standard for neonatal seizure diagnosis[J]. Semin Fetal Neonatal Med, 2015,20(3):149-153.

韩烨,符娜,秦炯.脑电图在新生儿惊厥诊断中的应用[J].癫痫杂志,2018,4(3):234-237.

Shellhaas RA, Chang T, Tsuchida T, et al. The American clinical neurophysiology society’s guideline on continuous electroencephalography monitoring in neonates[J]. J Clin Neurophysiol, 2011(28):611-617.

Nagarajan L, Ghosh S. Role of the video EEG in neonates with seizures. Neonatal seizures curr. Manag[J]. UK: Future chall. London, Mac KeithPress,2016.

杜琨,高瑾,邱丽玲,等.309例新生儿振幅整合脑电图分析[J].中国中西医结合儿科学,2021,13(5):413-416.

Ziobro JM, Eschbach K, Shellhaas RA. Novel Therapeutics for Neonatal Seizures[J]. Neurotherapeutics,2021,18(3):1564-1581.

Glass HC, Soul JS, Chu CJ, et al. Response to antiseizure medications in neonates with acute symptomatic seizures[J]. Epilepsia, 2019(60):e20-e24.

WHO Department of Mental Health and Substance Abuse, WHO Department of Maternal Newborn Child and Adolescent Health, OASI Department of Mental Retardation Unit of Neurology and Clinical Neurophysiopathology[J]. Guidelines on neonatal seizures. World Health Organ, 2011.

Sharpe C, Reiner GE, Davis SL, et al. Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial[J]. Pediatrics [Internet]. 2020(145):e20193182.

Young L, Berg M, Soll R. Prophylactic barbiturate use for the prevention of morbidity and mortality following perinatal asphyxia[J]. Cochrane Database Syst. Rev.[Internet]; 2016:5

(5):CD001240.

DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i3.16258