血清维生素D、HIF水平与原发性膜性肾病预后的相关性研究

柳 杨(承德医学院附属医院肾脏内科，中国)
兰 黄(承德医学院附属医院肾脏内科，中国)

摘要

维生素D主要在调节钙磷、骨骼代谢方面闻名，近期研究发现其抑制调节炎症反应对人类越来越有吸引力。HIF作为细胞缺氧反应的核心因子，在低氧环境中发挥着重要的调节功能，参与炎症、细胞代谢及凋亡等一系列反应。原发性膜性肾病发病机制主要为异常免疫反应介导的炎症疾病而引起的肾脏损伤。本综述探讨血清维生素D、HIF水平与原发性膜性肾病发展和预后的相关性，同时筛查其他影响原发性膜性肾病预后的危险因素，力求为延缓和治疗特发性膜性肾病提供新的治疗靶点。

关键词

维生素D；HIF；原发性膜性肾病

参考

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i2.16313