EB 病毒感染所致传染性单核细胞增多症发病机制研究进展

珍珍 李(承德医学院附属医院，中国)
鹏 孙(承德医学院附属医院，中国)

摘要

传染性单核细胞增多症（Infectious mononucleosis）是一种由EB病毒（Epstein-Barr virus）感染所致的临床综合征。IM在临床十分常见，但目前关于IM的发病机制尚未完全阐明。大量研究表明，IM的发病与EB病毒感染密切相关，EB病毒感染可引起机体免疫功能改变，甚至可有多系统受累，致使IM患儿的病情严重程度各不相同。IM多见于学龄前及学龄期儿童，而其发病机制与机体免疫系统密切相关。现有研究结果认为EB病毒载量、宿主免疫功能水平均可影响患儿病情的严重程度，论文就该病发病机制研究进展进行总结，加强对该病的认识，为临床提供多样化的诊疗思路。

关键词

传染性单核细胞增多症；EB病毒；免疫；发病机制

参考

诸福棠实用儿科学(第8版)[J].中国医刊,2015,50(3):48.

Tang S, Zhang R, Wang D, et al. Correlation of EpsteinBarr Virus Infection with Prognosis of Children with Acute

B Lymphoblastic Leukemia[J]. Zhongguoshi yanxue yexue

zazhi,2019,27(3):769-776.

Thorley-Lawson D A. Epstein-Barr virus: exploiting the immune

system[J]. Nature Reviews Immunology,2001,1(1):75-82.

方莉萍,邵丽佳,吴俊琪.传染性单核细胞增多症患儿多个临床检

测指标的临床意义[J].全科医学临床与教育,2016,14(2):193-194.

乔燕伟.传染性单核细胞增多症研究进展[J].河北医药,2020,42

(22):3472-3476.

韩红满,李四强.传染性单核细胞增多症相关免疫学研究进展[J].

医学综述,2020,26(3):443-447+452.

Iwona S, Malgorzata P, Tomasz G, et al. Humoral and cellular

immunity in children with Mycoplasma pneumoniae infection: a

-year prospective study[J]. Clinical and diagnostic laboratory im

munology,2005,12(10):1246-1250.

Rostgaard K, Balfour HH Jr, Jarrett R, et al. Primary Epstein-Barr

virus infection with and without infectious mononucleosis[J]. PLoS

One,2019,14(12):e0226436.

Xi H, Kersh G J. Sustained early growth response gene 3

expression inhibits the survival of CD4/CD8 double-positive

thymocytes[J]. The Journal of Immunology,2004,173(1):340-348.

Zhang Z X, Yang L, Young K J, et al. Identification of a previously

unknown antigen-specific regulatory T cell and its mechanism of

suppression[J]. Nature medicine,2000,6(7):782-789.

葛华,杨新蔚,袁帆.非霍奇金淋巴瘤患者化疗前后T淋巴细胞亚

群变化及临床意义[J].内科2016,11(3):398-400.

范小红,孟亚红,邹健等.乙肝表面抗原阳性的非霍奇金淋巴瘤患

者化疗前后T淋巴细胞亚群的变化[J].现代中西医结合杂志，

,25(9):920-922+925.

马春华,张霞,丁慧.人免疫球蛋白联合甲强龙治疗支原体肺

炎合并EB病毒感染患者的临床疗效[J].中华医院感染学杂

志,2013,23(22):5527-5529.

祁建凤,舒静娜.免疫指标检测对传染性单核细胞增多症与慢

性活动性EB病毒感染的鉴别诊断价值[J].中国基层医药,2020,

(4):475-478.

Fedyanina OS, Filippova AE, Demina OI, et al. The Nature and

Clinical Significance of Atypical Mononuclear Cells in Infectious

Mononucleosis Caused by the Epstein-Barr Virus in Children[J]. J

Infect Dis.2021,223(10):1699-1706.

Williams H, Macsween K, McAulay K, et al. Analysis of immune

activation and clinical events in acute infectious mononucleosis[J].

The Journal of infectious diseases,2004,190(1):53-62.

陈伟雄.外周血异型淋巴细胞增高细胞免疫变化的探讨[J].临床

和实验医学杂志,2007(4):90-91.

Jayasooriya S, de Silva TI, Njie-jobe J,et al. Early virological and

immunological events in asymptomatic Epstein-Barr virus infection

in African children[J]. PLoS Pathog. 2015,11(3):e1004746.

Naughton P, Healy M, Enright F, Lucey B. Infectious

Mononucleosis: diagnosis and clinical interpretation[J]. Br J

Biomed Sci, 2021,78(3):107-116.

Mendoza N, Diamantis M, Arora A, et al. Mucocutaneous

manifestations of Epstein-Barr virus infection[J]. American journal

of clinical dermatology,2008(9):295-305.

DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i2.16328