血清胎球蛋白Ａ、低氧诱导因子1在心血管疾病中的作用

艺心 卢(承德医学院附属医院，中国)
一鹏 林(承德医学院附属医院，中国)
胜男 翟(承德医学院附属医院，中国)
强 张(承德医学院附属医院，中国)
瑞田 侯(承德医学院附属医院，中国)

摘要

血清胎球蛋白A（Fetuin-A）是来自胱抑素超家族的血浆糖蛋白，主要由肝脏产生，它参与调控肿瘤发生发展、钙和骨的代谢、胰岛素抵抗等生物学效应，还在心血管相关疾病中发挥重要作用。Fetuin-A主要通过抑制异位钙化来减少心血管疾病（CVD）患病风险，并通过刺激人主动脉平滑肌细胞增殖及增强胰岛素抵抗等作用而加剧CVD患病风险。低氧诱导因子1（HIF-1）是目前生物医学研究领域的热点分子之一，近期研究表明，血清HIF-1水平与心血管疾病如动脉粥样硬化、冠状动脉粥样硬化性心脏病、高血压病和心力衰竭等关系密切。论文主要介绍Fetuin-A、HIF-1与心血管相关疾病的关系。

关键词

血清胎球蛋白A；低氧诱导因子1；心血管疾病

参考

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DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i4.17055