细胞骨架Fascin-1与Notch信号通路在胃癌中的研究进展

颖萍 熊(承德医学院附属医院，中国)
春辉 李(承德医学院附属医院，中国)

摘要

胃癌（Gastric Cancer，GC）作为胃肠道常见的恶性肿瘤之一，其发生发展受多因素影响。胃癌起病隐匿，绝大部分患者就诊时已为晚期，而临床上治疗局限，迫切需要新的治疗方法及药物。Fascin-1作为Fascin家族成员之一，是参与细胞骨架调节最多的分子之一，与肿瘤的侵袭迁移关系密切。Notch信号通路是一条进化上保守的信号通路，与肿瘤的发生、发展密切相关。论文针对Fascin-1及Notch信号通路的结构与功能及与胃癌之间的关系进行综述，总结最新研究进展，为胃癌的治疗提供新思路和方向。

关键词

胃癌；Notch信号通路；Fascin-1

参考

胃癌诊疗规范(2018年版)[J].中华消化病与影像杂志(电子版),2019,9(3):118-144.

LI C H, CHAN M H, LIANG S M, et al. Fascin-1: Updated biological functions and therapeutic implications in cancer biology[J]. BBA Adv, 2022,2:100052.

LI L, TANG P, LI S, et al. Notch signaling pathway networks in cancer metastasis: a new target for cancer therapy[J]. Med Oncol, 2017,34(10):180.

ZHOU B, LIN W, LONG Y, et al. Notch signaling pathway: architecture, disease, and therapeutics[J]. Signal Transduct Target Ther, 2022,7(1):95.

LIU H, ZHANG Y, LI L, et al. Fascin actin-bundling protein 1 in human cancer: promising biomarker or therapeutic target?[J]. Mol Ther Oncolytics, 2021,20:240-264.

LAMB M C, TOOTLE T L. Fascin in Cell Migration: More Than an Actin Bundling Protein[J]. Biology (Basel), 2020,9(11):403.

ZHANG N, GAO Y, BIAN Q, et al. The role of fascin-1 in the pathogenesis, diagnosis and management of respiratory related cancers[J]. Front Oncol, 2022,12:948110.

PISKOR B M, PRYCZYNICZ A, LUBOWICKA E, et al. Immunohistochemical expression of Fascin-1 in colorectal cancer in relation to clinical and pathological parameters[J]. Folia Histochem Cytobiol, 2018,1(2):106-112.

WANG C Q, TANG C H, CHANG H T, et al. Fascin-1 as a novel diagnostic marker of triple-negative breast cancer[J]. Cancer Med, 2016,5(8):1983-1988.

SARANTELLI E, MOURKAKIS A, ZACHARIA L C, et al. Fascin-1 in Cancer Cell Metastasis: Old Target-New Insights[J]. Int J Mol Sci, 2023,24(14):11253.

RISTIC B, KOPEL J, SHERAZI S, et al. Emerging Role of Fascin-1 in the Pathogenesis, Diagnosis, and Treatment of the Gastrointestinal Cancers[J]. Cancers (Basel), 2021,13(11):2536.

KIM S J, CHOI I J, CHEONG T C, et al. Galectin-3 increases gastric cancer cell motility by up-regulating fascin-1 expression[J]. Gastroenterology, 2010,138(3):1035-1045.e1-2.

TU L, XU J, WANG M, et al. Correlations of fascin-1 and cadherin-17 protein expression with clinicopathologic features and prognosis of patients with gastric cancer[J]. Tumour Biol, 2016,37(7):8775-8782.

赵文兴,王振,李磊,等.Fascin1与E-cadherin在胃癌中的表达与意义[J].山东第一医科大学(山东省医学科学院)学报,2021,42(8):568-572.

KOPAN R, ILAGAN M X. The canonical Notch signaling pathway: unfolding the activation mechanism[J]. Cell, 2009,137(2):216-233.

SPRINZAK D, BLACKLOW S C. Biophysics of Notch Signaling[J]. Annu Rev Biophys,2021,50:157-189.

MAJUMDER S, CRABTREE J S, GOLDE T E, et al. Targeting Notch in oncology: the path forward[J]. Nat Rev Drug Discov,2021,20(2):125-144.

KATOH M, KATOH M. Precision medicine for human cancers with Notch signaling dysregulation (Review)[J]. Int J Mol Med,2020,45(2):279-297.

HU J, YU J, GAN J, et al. Notch1/2/3/4 are prognostic biomarker and correlated with immune infiltrates in gastric cancer[J]. Aging (Albany NY), 2020,12(3):2595-2609.

HIBDON E S, RAZUMILAVA N, KEELEY T M, et al. Notch and mTOR Signaling Pathways Promote Human Gastric Cancer Cell Proliferation[J]. Neoplasia, 2019,21(7):702-712.

史志猛.Notch1信号通路通过调节Fascin1的表达促进胃癌结肠癌侵袭与转移的机制研究[D].武汉:武汉大学,2020.

XIE L, YAN J. γ-tocotrienol regulates gastric cancer by targeting notch signaling pathway[J]. Hereditas, 2023,160(1):15.

葛宁,姜媛媛,潘中平,等.叉头框M1调控circ＿NOTCH1对胃癌细胞增殖、侵袭及耐药性的影响[J].中国医学科学院学报,2023,45(5):713-720.

DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i4.17095