开放期刊系统

关于脓毒症相关性脑病发生发展机制的研究

子玉 鄂(承德医学院附属医院急诊医学科,中国)
健 于(承德医学院附属医院急诊医学科,中国)

摘要

在急危重症的工作当中,脓毒症是我们常常碰到的高死亡率疾病,然而对于脓毒症的治疗手段目前仍局限于对症支持治 疗,这也导致脓毒症的死亡率居高不下,成为严重威胁人类生命健康的重要疾病之一。脓毒症的定义为机体对感染的异常 反应失调所引起的危及生命的器官功能障碍,脓毒症是指一系列器官功能障碍的总称。大脑作为人体的中枢神经,在脓毒 症早期经常发生脑功能障碍,称为脓毒症相关性脑病,但是明确的发生发展机制尚不明确。论文主要综述脓毒症相关性脑 病发生发展的相关机制,为脓毒症的治疗提供新的思路。

关键词

脓毒症;脓毒症相关性脑病;细胞焦亡;凋亡

全文:

PDF

参考

Singer M, Deutschman S C, Seymour W C, et al. The Third

International Consensus Definitions for Sepsis and Septic Shock

(Sepsis-3)[J]. JAMA, 2016,315(8):801-810.

Koji H, Nicolas G, Fuhong S, et al. Clinical neurophysiological

assessment of sepsis-associated brain dysfunction: a systematic

review[J]. Critical care (London, England), 2014,18(6):674.

L E S, M C C, Tatiana B, et al. The septic brain[J]. Neurochemical

research, 2008,33(11):2171-2177.

Sieh J D, Siqi L, Lili L, et al. Effects of hydrogen-rich saline in

neuroinflammation and mitochondrial dysfunction in rat model

of sepsis-associated encephalopathy[J]. Journal of Translational

Medicine, 2022,20(1):546.

Pytel P, Alexander J J. Pathogenesis of septic encephalopathy[J].

Curr Opin Neurol, 2009,22(3):283-287.

董艳,刘刚,张力,等.大黄素对脓毒症小鼠急性脑损伤的神经保护

作用[J].解放军医学杂志,2019,44(1):13-19.

Qingzeng G, Sorrentino M H. Sepsis-Associated Encephalopathy

and Blood-Brain Barrier Dysfunction[J]. Inflammation,

,44(6):1-9.

朱丹丹,于健,陆莹莹.脓毒症相关性脑病的发病机制和潜在脑损

伤标志物[J].实用休克杂志(中英文),2019,3(3):171-175.

A F B, C J D, Cristiane R, et al. Bioenergetics, mitochondrial

dysfunction, and oxidative stress in the pathophysiology of septic

encephalopathy[J].Shock (Augusta, Ga.),2013,39 Suppl 1(7 Suppl

:10-16.

Shangwen P, Zheng L, Rui W, et al. Sepsis-Induced Brain

Dysfunction: Pathogenesis, Diagnosis, and Treatment[J]. Oxidative

medicine and cellular longevity, 2022,20221328729.

Integrative analysis of metabolomics and proteomics reveals amino

acid metabolism disorder in sepsis[J]. Journal of Translational

Medicine, 2022, 20(1):1-15.

李志强,周艺蕉,杨春燕.脓毒症脑病发病机制的研究进展[J].医

学综述,2021,27(19):3791-3795.

李文玉,杨洪娜,方巍,等.脓毒症相关性脑病的研究进展[J].山东

第一医科大学(山东省医学科学院)学报,2023,44(9):707-711.

Santiago S P A, Chaves A E, Oliveira F M, et al. Reactive oxygen

species generation is modulated by mitochondrial kinases:

Correlation with mitochondrial antioxidant peroxidases in rat

tissues[J]. Biochimie, 2008,90(10):1566-1577.

王诚,王昌理,薄禄龙,等.脓毒症时细胞焦亡的分子机制及研究进

展[J].实用休克杂志(中英文),2019,3(4):232-235.

Xiangtao Z, Weiwei C, Fangchen G, et al. The Role and

Mechanism of Pyroptosis and Potential Therapeutic Targets in

Sepsis: A Review[J]. Frontiers in Immunology, 2021,12711939.

Daolin T, Haichao W, R. T B, et al. Emerging mechanisms of

immunocoagulation in sepsis and septic shock[J]. Trends in

Immunology, 2021,42(6):508-522.

Yang D, He Y, Muñoz-Planillo R, et al. Caspase-11 Requires the

Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate

Pyroptosis and Endotoxic Shock[J]. Immunity,2015,43(5):923-932.

Romain S, Etienne M D, Julien P, et al. Potentially modifiable

factors contributing to sepsis-associated encephalopathy[J].

Intensive care medicine, 2017,43(8):1075-1084.

PPP, DRS, DTG, et al. Effect of dexmedetomidine versus

lorazepam on outcome in patients with sepsis: an a priori-designed

analysis of the MENDS randomized controlled trial[J]. Critical

care (London, England), 2010,14(2):R38.

隋大鸣.白藜芦醇对脓毒症相关性脑病小鼠海马的保护作用[D].

上海:第二军医大学,2015.

刘玲玲.氢气对脓毒症小鼠脑损伤的保护作用及其相关机制[D].

天津:天津医科大学,2015.

Xu X, Liu L, Wang Y, et al. Caspase-1 inhibitor exerts brainprotective effects against sepsis-associated encephalopathy and

cognitive impairments in a mouse model of sepsis[J]. Brain

Behavior and Immunity, 2019,80859-80870.



DOI: http://dx.doi.org/10.12345/yzlcyxzz.v7i5.17758

Refbacks

  • 当前没有refback。
版权所有(c)2024 子玉 鄂, 健 于 Creative Commons License
此作品已接受知识共享署名-非商业性使用 4.0国际许可协议的许可。
  • :+65-62233778 QQ:2249355960 :contact@s-p.sg